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2018 ; 41
(5
): 2704-2714
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Long noncoding RNA ENSRNOG00000037522 is involved in the podocyte
epithelial?mesenchymal transition in diabetic rats
#MMPMID29436579
Ling L
; Tan Z
; Zhang C
; Gui S
; Hu Y
; Chen L
Int J Mol Med
2018[May]; 41
(5
): 2704-2714
PMID29436579
show ga
Diabetic nephropathy (DN) is one of the most common complications associated with
type I and II diabetes mellitus. Long noncoding RNAs (lncRNAs) have been
implicated in various physiological and pathological processes, and recent
evidence has demonstrated that they are involved in the process of the
epithelial?mesenchymal transition (EMT). In the present study, the potential
functions of lncRNA ENSRNOG00000037522 during the EMT process in DN were
investigated. The results identified that the level of the lncRNA
ENSRNOG00000037522 was significantly increased in kidney tissues collected from
rats with streptozocin (STZ)?induced DN accompanied by impairment of the
glomerular podocytes. It was further demonstrated that the silencing of lncRNA
ENSRNOG00000037522 by small interfering RNA transfection partially restored the
podocyte function. In addition, knockdown of lncRNA ENSRNOG00000037522 repaired
the damage to the podocytes via regulating vimentin, podocalyxin?like 1 and
nephrin expression. In conclusion, the current results demonstrated that lncRNA
ENSRNOG00000037522 serves a pivotal role in the podocyte EMT in DN.