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10.1155/2018/8658507

http://scihub22266oqcxt.onion/10.1155/2018/8658507
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C5846347!5846347!29682100
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suck abstract from ncbi


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pmid29682100      Dis+Markers 2018 ; 2018 (ä): ä
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  • Urinary Clusterin Is Upregulated in Nephropathia Epidemica #MMPMID29682100
  • Martynova EV; Maksudova AN; Shakirova VG; Abdulkhakov SR; Khaertynova IM; Anokhin VA; Ivanova VV; Abiola IM; Garanina EE; Tazetdinova LG; Valiullina AH; Khaiboullina SF
  • Dis Markers 2018[]; 2018 (ä): ä PMID29682100show ga
  • Kidney insufficiency is a hallmark of nephropathia epidemica (NE). Little is known about the mechanisms of the NE kidney pathology, with current knowledge mainly based on findings in postmortem tissue. We have analyzed kidney damage biomarkers in urine collected from early- and late-phase NE using Bio-Plex kidney toxicity panels 1 and 2. To determine the disease specificity, kidney damage biomarkers were also analyzed in urine samples from patients diagnosed with gout, type 2 diabetes, systemic lupus erythematosus, and chronic kidney insufficiency. Analysis of 12 biomarkers suggests damage to the kidney proximal tubule at the onset of NE. Also, upregulation of biomarkers of inflammation and leukocyte chemotaxis were detected in NE urine. Furthermore, increased clusterin levels were found in early- and late-phase NE urine. Comparative analysis revealed that clusterin is a biomarker, upregulated in NE urine.
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