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2018 ; 10
(ä): 55
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Altered Brain Functional Hubs and Connectivity in Type 2 Diabetes Mellitus
Patients: A Resting-State fMRI Study
#MMPMID29563869
Liu D
; Duan S
; Zhou C
; Wei P
; Chen L
; Yin X
; Zhang J
; Wang J
Front Aging Neurosci
2018[]; 10
(ä): 55
PMID29563869
show ga
Type 2 diabetes mellitus (T2DM) affects a vast population and is closely
associated with cognitive impairment. However, the mechanisms of cognitive
impairment in T2DM patients have not been unraveled. Research on the basic units
(nodes or hubs and edges) of the brain functional network on the basis of
neuroimaging may advance our understanding of the network change pattern in T2DM
patients. This study investigated the change patterns of brain functional hubs
using degree centrality (DC) analysis and the connectivity among these hubs using
functional connectivity and Granger causality analysis. Compared to healthy
controls, the DC values were higher in the left anterior cingulate gyrus (ACG)
and lower in the bilateral lateral occipital cortices (LOC) and right precentral
gyrus (PreCG) in T2DM patients. The functional connectivity between the left ACG
and the right PreCG was stronger in T2DM patients, whereas the functional
connectivity among the right PreCG and bilateral LOC was weaker. A negative
causal effect from the left ACG to left LOC and a positive effect from the left
ACG to right LOC were observed in T2DM patients, while in healthy controls, the
opposite occurred. Additionally, the reserve of normal brain function in T2DM
patients was negatively associated with the elevated glycemic parameters. This
study demonstrates that there are brain functional hubs and connectivity
alterations that may reflect the aberrant information communication in the brain
of T2DM patients. The findings may advance our understanding of the mechanisms of
T2DM-related cognitive impairment.