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10.1136/openhrt-2017-000712 http://scihub22266oqcxt.onion/10.1136/openhrt-2017-000712 C5845414!5845414!29531758     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Open+Heart 2018 ; 5 (1): ä Nephropedia Template TP {{tp|p=29531758|t=2018. Direct oral anticoagulants versus warfarin: is new always better than the old?|pdf=|usr=}}{{29531758}} gab.com Text Direct oral anticoagulants versus warfarin: is new always better than the old JO: Open Heart http://www.kidney.de/pget.php?&tw=1&pmid=29531758 #FOAvip About 1.4 British million people are at risk of strokes due to non-valvular atrial fibrillation (AF) necessitating long-term anticoagulation. The vitamin K antagonist, warfarin, has a long half-life and narrow therapeutic range necessitating regular monitoring and is a common cause of iatrogenic hospital admission. Direct-acting oral anticoagulants (DOACs), dabigatran, rivaroxaban, apixaban and edoxaban are not required to have monitoring but are sensitive to changes in renal function and are associated with poorer adherence. There are good grounds to believe that DOACs are not always superior to warfarin in routine practice particularly with an older population. Much higher levels of therapeutic effectiveness can be achieved using a simple genotype guidance to identify those who are highly sensitive and by adoption of home monitoring. These adjustments could make warfarin the preferred drug for most people and would reduce the dramatic rise in health service expenditure. Twit Text FOAVip Direct oral anticoagulants versus warfarin: is new always better than the old ????Open Heart http://www.kidney.de/pget.php?&tw=1&pmid=29531758 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29531758 #FOAvip English Wikipedia <ref>{{Cite pmid|29531758}}</ref> Direct oral anticoagulants versus warfarin: is new always better than the old? #MMPMID29531758 Burn J; Pirmohamed M Open Heart 2018[]; 5 (1): ä PMID29531758show ga About 1.4 British million people are at risk of strokes due to non-valvular atrial fibrillation (AF) necessitating long-term anticoagulation. The vitamin K antagonist, warfarin, has a long half-life and narrow therapeutic range necessitating regular monitoring and is a common cause of iatrogenic hospital admission. Direct-acting oral anticoagulants (DOACs), dabigatran, rivaroxaban, apixaban and edoxaban are not required to have monitoring but are sensitive to changes in renal function and are associated with poorer adherence. There are good grounds to believe that DOACs are not always superior to warfarin in routine practice particularly with an older population. Much higher levels of therapeutic effectiveness can be achieved using a simple genotype guidance to identify those who are highly sensitive and by adoption of home monitoring. These adjustments could make warfarin the preferred drug for most people and would reduce the dramatic rise in health service expenditure. äDirect oral anticoagulants versus warfarin: is new always better than (epmc).pdf DeepDyve Pubget Overpricing