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10.1186/s12943-018-0821-1 http://scihub22266oqcxt.onion/10.1186/s12943-018-0821-1 C5845323!5845323 !29523145     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29523145 &cmd=llinks): Failed to open stream: HTTP request failed! 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Linc00659, a long noncoding RNA, acts as novel oncogene in regulating cancer cell growth in colorectal cancer |pdf=|usr=}}{{29523145 }} gab.com Text Linc00659, a long noncoding RNA, acts as novel oncogene in regulating cancer cell growth in colorectal cancer JO: Mol Cancer http://www.kidney.de/pget.php?&tw=1&pmid=29523145 #FOAvip BACKGROUND: Colorectal cancer (CRC) is one of the most common cancers and causes of cancer-related death worldwide. In patients with CRC, metastasis is a crucial problem that leads to treatment failure and is the primary cause of the lethality of colon cancer. Long noncoding RNAs (lncRNAs) have recently emerged as critical molecules in the development, cell growth, apoptosis, and metastasis of CRC. METHOD: We investigated the transcriptome profiles of human lncRNAs in the primary tumor tissues and in the corresponding normal mucosa of two patients with CRC by using a microarray approach. The expression levels of lncRNAs were verified in colon cancer by real-time PCR. Using bioinformatics approach to illustrate putative biological function of Linc00659 in colon cancer. The effects of Linc00659 on cell growth, proliferation, cell cycle and apoptosis were studies by in vitro assays. RESULTS: Our data revealed that compared with adjacent normal tissues, 201 lncRNAs were deregulated (fold change ??4 or ??0.25) in CRC tissues. Among them, the expression levels of Linc00659 were significantly increased in colon cancer, and high expression levels were correlated with poor survival in patients with CRC. Bioinformatics analysis results indicated that Linc00659 was significantly coexpressed with cycle-related genes in CRC. Linc00659 expression knockdown could significantly suppress colon cancer cell growth by impairing cell cycle progression. In addition, our results showed that Linc00659 expression knockdown could accelerate cell apoptosis in colon cancer cells treated with chemotherapy drugs. Meanwhile, our results also demonstrated that silencing of Linc00659 expression leads to cell growth inhibition and induced apoptosis, possibly by suppressing PI3K-AKT signaling in colon cancer. CONCLUSION: Linc00659 is a novel oncogenic lncRNA involved in colon cancer cell growth by modulating the cell cycle. Our findings give an insight into lncRNA regulation and provide an application for colon cancer therapy. Twit Text FOAVip Linc00659, a long noncoding RNA, acts as novel oncogene in regulating cancer cell growth in colorectal cancer ????Mol Cancer http://www.kidney.de/pget.php?&tw=1&pmid=29523145 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29523145 #FOAvip English Wikipedia <ref>{{Cite pmid|29523145 }}</ref> Linc00659, a long noncoding RNA, acts as novel oncogene in regulating cancer cell growth in colorectal cancer #MMPMID29523145 Tsai KW ; Lo YH ; Liu H ; Yeh CY ; Chen YZ ; Hsu CW ; Chen WS ; Wang JH Mol Cancer 2018[Mar]; 17 (1 ): 72 PMID29523145 show ga BACKGROUND: Colorectal cancer (CRC) is one of the most common cancers and causes of cancer-related death worldwide. In patients with CRC, metastasis is a crucial problem that leads to treatment failure and is the primary cause of the lethality of colon cancer. Long noncoding RNAs (lncRNAs) have recently emerged as critical molecules in the development, cell growth, apoptosis, and metastasis of CRC. METHOD: We investigated the transcriptome profiles of human lncRNAs in the primary tumor tissues and in the corresponding normal mucosa of two patients with CRC by using a microarray approach. The expression levels of lncRNAs were verified in colon cancer by real-time PCR. Using bioinformatics approach to illustrate putative biological function of Linc00659 in colon cancer. The effects of Linc00659 on cell growth, proliferation, cell cycle and apoptosis were studies by in vitro assays. RESULTS: Our data revealed that compared with adjacent normal tissues, 201 lncRNAs were deregulated (fold change ??4 or ??0.25) in CRC tissues. Among them, the expression levels of Linc00659 were significantly increased in colon cancer, and high expression levels were correlated with poor survival in patients with CRC. Bioinformatics analysis results indicated that Linc00659 was significantly coexpressed with cycle-related genes in CRC. Linc00659 expression knockdown could significantly suppress colon cancer cell growth by impairing cell cycle progression. In addition, our results showed that Linc00659 expression knockdown could accelerate cell apoptosis in colon cancer cells treated with chemotherapy drugs. Meanwhile, our results also demonstrated that silencing of Linc00659 expression leads to cell growth inhibition and induced apoptosis, possibly by suppressing PI3K-AKT signaling in colon cancer. CONCLUSION: Linc00659 is a novel oncogenic lncRNA involved in colon cancer cell growth by modulating the cell cycle. Our findings give an insight into lncRNA regulation and provide an application for colon cancer therapy. |*Gene Expression Regulation, Neoplastic [MESH] |*Oncogenes [MESH] |Apoptosis/genetics [MESH] |Biomarkers, Tumor [MESH] |Cell Cycle/genetics [MESH] |Cell Line, Tumor [MESH] |Colorectal Neoplasms/*genetics/metabolism/mortality/pathology [MESH] |Gene Expression Profiling [MESH] |Gene Knockdown Techniques [MESH] |Humans [MESH] |Models, Biological [MESH] |Phosphatidylinositol 3-Kinases/metabolism [MESH] |Prognosis [MESH] |Proto-Oncogene Proteins c-akt/metabolism [MESH] |RNA, Long Noncoding/*genetics [MESH] |Signal Transduction [MESH]Linc00659, a long noncoding RNA, acts as novel oncogene in regulating (epmc).pdf DeepDyve Pubget Overpricing