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2018 ; 18
(ä): 35
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Overexpression of Rab11-FIP2 in colorectal cancer cells promotes tumor migration
and angiogenesis through increasing secretion of PAI-1
#MMPMID29540997
Dong W
; Wu X
Cancer Cell Int
2018[]; 18
(ä): 35
PMID29540997
show ga
BACKGROUND: Rab11 family-interacting protein 2 (Rab11-FIP2) can interact with
MYO5B and plays an important role in regulating plasma membrane recycling.
However, little is known about the clinical significance of DUSP2 in colorectal
cancer (CRC). METHODS: In this study, we investigated Rab11-FIP2 expression by
immunohistochemistry in 125 patients with colorectal cancer. Conditioned media
containing all secreted factors was harvested. Chemokine secretion and expression
were analyzed by Chemi-array. RESULTS: We found that the expression level of
Rab11-FIP2 was significantly increased in colorectal cancer tissues and high
expression of Rab11-FIP2 was closely correlated with nodal metastasis in
colorectal cancer patients. Rab11-FIP2 overexpression promoted colorectal cancer
metastasis in vitro and in vivo. Finally, we demonstrated that Rab11-FIP2
overexpression may contribute to increased secretion of PAI-1 in human colorectal
cancer cells. CONCLUSIONS: Our findings reveal a novel mechanism underlying the
role of Rab11-FIP2 in colorectal cancer dissemination, suggesting that targeting
Rab11-FIP2 might be a promising therapeutic strategy for CRC.