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10.3389/fimmu.2018.00321 http://scihub22266oqcxt.onion/10.3389/fimmu.2018.00321 C5844930!5844930!29556227     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2018 ; 9 (ä): ä Nephropedia Template TP {{tp|p=29556227|t=2018. PIRCHE-II Is Related to Graft Failure after Kidney Transplantation |pdf=|usr=}}{{29556227}} gab.com Text PIRCHE-II Is Related to Graft Failure after Kidney Transplantation JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29556227 #FOAvip Individual HLA mismatches may differentially impact graft survival after kidney transplantation. Therefore, there is a need for a reliable tool to define permissible HLA mismatches in kidney transplantation. We previously demonstrated that donor-derived Predicted Indirectly ReCognizable HLA Epitopes presented by recipient HLA class II (PIRCHE-II) play a role in de novo donor-specific HLA antibodies formation after kidney transplantation. In the present Dutch multi-center study, we evaluated the possible association between PIRCHE-II and kidney graft failure in 2,918 donor?recipient couples that were transplanted between 1995 and 2005. For these donors?recipients couples, PIRCHE-II numbers were related to graft survival in univariate and multivariable analyses. Adjusted for confounders, the natural logarithm of PIRCHE-II was associated with a higher risk for graft failure [hazard ratio (HR): 1.13, 95% CI: 1.04?1.23, p?=?0.003]. When analyzing a subgroup of patients who had their first transplantation, the HR of graft failure for ln(PIRCHE-II) was higher compared with the overall cohort (HR: 1.22, 95% CI: 1.10?1.34, p?<?0.001). PIRCHE-II demonstrated both early and late effects on graft failure in this subgroup. These data suggest that the PIRCHE-II may impact graft survival after kidney transplantation. Inclusion of PIRCHE-II in donor-selection criteria may eventually lead to an improved kidney graft survival. Twit Text FOAVip PIRCHE-II Is Related to Graft Failure after Kidney Transplantation ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29556227 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29556227 #FOAvip English Wikipedia <ref>{{Cite pmid|29556227}}</ref> PIRCHE-II Is Related to Graft Failure after Kidney Transplantation #MMPMID29556227 Geneugelijk K; Niemann M; Drylewicz J; van Zuilen AD; Joosten I; Allebes WA; van der Meer A; Hilbrands LB; Baas MC; Hack CE; van Reekum FE; Verhaar MC; Kamburova EG; Bots ML; Seelen MAJ; Sanders JS; Hepkema BG; Lambeck AJ; Bungener LB; Roozendaal C; Tilanus MGJ; Vanderlocht J; Voorter CE; Wieten L; van Duijnhoven EM; Gelens M; Christiaans MHL; van Ittersum FJ; Nurmohamed A; Lardy JNM; Swelsen W; van der Pant KA; van der Weerd NC; ten Berge IJM; Bemelman FJ; Hoitsma A; van der Boog PJM; de Fijter JW; Betjes MGH; Heidt S; Roelen DL; Claas FH; Otten HG; Spierings E Front Immunol 2018[]; 9 (ä): ä PMID29556227show ga Individual HLA mismatches may differentially impact graft survival after kidney transplantation. Therefore, there is a need for a reliable tool to define permissible HLA mismatches in kidney transplantation. We previously demonstrated that donor-derived Predicted Indirectly ReCognizable HLA Epitopes presented by recipient HLA class II (PIRCHE-II) play a role in de novo donor-specific HLA antibodies formation after kidney transplantation. In the present Dutch multi-center study, we evaluated the possible association between PIRCHE-II and kidney graft failure in 2,918 donor?recipient couples that were transplanted between 1995 and 2005. For these donors?recipients couples, PIRCHE-II numbers were related to graft survival in univariate and multivariable analyses. Adjusted for confounders, the natural logarithm of PIRCHE-II was associated with a higher risk for graft failure [hazard ratio (HR): 1.13, 95% CI: 1.04?1.23, p?=?0.003]. When analyzing a subgroup of patients who had their first transplantation, the HR of graft failure for ln(PIRCHE-II) was higher compared with the overall cohort (HR: 1.22, 95% CI: 1.10?1.34, p? äPIRCHE-II Is Related to Graft Failure after Kidney Transplantation (epmc).pdf DeepDyve Pubget Overpricing