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SLIT2/ROBO1 axis contributes to the Warburg effect in osteosarcoma through
activation of SRC/ERK/c-MYC/PFKFB2 pathway
#MMPMID29523788
Zhao SJ
; Shen YF
; Li Q
; He YJ
; Zhang YK
; Hu LP
; Jiang YQ
; Xu NW
; Wang YJ
; Li J
; Wang YH
; Liu F
; Zhang R
; Yin GY
; Tang JH
; Zhou D
; Zhang ZG
Cell Death Dis
2018[Mar]; 9
(3
): 390
PMID29523788
show ga
Cellular metabolic reprogramming is the main characteristic of cancer cells and
identification of targets using this metabolic pattern is extremely important to
treat cancers, such as osteosarcoma (OS). In this study, SLIT2 and ROBO1 were
upregulated in OS, and higher expression of ROBO1 was associated with worse
overall survival rate. Furthermore, in vitro and in vivo experiments demonstrated
that the SLIT2/ROBO1 axis promotes proliferation, inhibits apoptosis, and
contributes to the Warburg effect in OS cells. Mechanistically, the SLIT2/ROBO1
axis exerted cancer-promoting effects on OS via activation of the
SRC/ERK/c-MYC/PFKFB2 pathway. Taken together, the findings reveal a previously
unappreciated function of SLIT2/ROBO1 signaling in OS, which is intertwined with
metabolic alterations that promote cancer progression. Targeting the SLIT2/ROBO1
axis may be a potential therapeutic approach for patients with OS.
|Animals
[MESH]
|Glycolysis
[MESH]
|Heterografts
[MESH]
|Humans
[MESH]
|Intercellular Signaling Peptides and Proteins/genetics/*metabolism
[MESH]
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