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10.1038/s41419-018-0419-y http://scihub22266oqcxt.onion/10.1038/s41419-018-0419-y C5844886!5844886 !29523788     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29523788 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Death+Dis 2018 ; 9 (3 ): 390 Nephropedia Template TP {{tp|p=29523788 |t=2018. SLIT2/ROBO1 axis contributes to the Warburg effect in osteosarcoma through activation of SRC/ERK/c-MYC/PFKFB2 pathway |pdf=|usr=}}{{29523788 }} gab.com Text SLIT2/ROBO1 axis contributes to the Warburg effect in osteosarcoma through activation of SRC/ERK/c-MYC/PFKFB2 pathway JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=29523788 #FOAvip Cellular metabolic reprogramming is the main characteristic of cancer cells and identification of targets using this metabolic pattern is extremely important to treat cancers, such as osteosarcoma (OS). In this study, SLIT2 and ROBO1 were upregulated in OS, and higher expression of ROBO1 was associated with worse overall survival rate. Furthermore, in vitro and in vivo experiments demonstrated that the SLIT2/ROBO1 axis promotes proliferation, inhibits apoptosis, and contributes to the Warburg effect in OS cells. Mechanistically, the SLIT2/ROBO1 axis exerted cancer-promoting effects on OS via activation of the SRC/ERK/c-MYC/PFKFB2 pathway. Taken together, the findings reveal a previously unappreciated function of SLIT2/ROBO1 signaling in OS, which is intertwined with metabolic alterations that promote cancer progression. Targeting the SLIT2/ROBO1 axis may be a potential therapeutic approach for patients with OS. Twit Text FOAVip SLIT2/ROBO1 axis contributes to the Warburg effect in osteosarcoma through activation of SRC/ERK/c-MYC/PFKFB2 pathway ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=29523788 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29523788 #FOAvip English Wikipedia <ref>{{Cite pmid|29523788 }}</ref> SLIT2/ROBO1 axis contributes to the Warburg effect in osteosarcoma through activation of SRC/ERK/c-MYC/PFKFB2 pathway #MMPMID29523788 Zhao SJ ; Shen YF ; Li Q ; He YJ ; Zhang YK ; Hu LP ; Jiang YQ ; Xu NW ; Wang YJ ; Li J ; Wang YH ; Liu F ; Zhang R ; Yin GY ; Tang JH ; Zhou D ; Zhang ZG Cell Death Dis 2018[Mar]; 9 (3 ): 390 PMID29523788 show ga Cellular metabolic reprogramming is the main characteristic of cancer cells and identification of targets using this metabolic pattern is extremely important to treat cancers, such as osteosarcoma (OS). In this study, SLIT2 and ROBO1 were upregulated in OS, and higher expression of ROBO1 was associated with worse overall survival rate. Furthermore, in vitro and in vivo experiments demonstrated that the SLIT2/ROBO1 axis promotes proliferation, inhibits apoptosis, and contributes to the Warburg effect in OS cells. Mechanistically, the SLIT2/ROBO1 axis exerted cancer-promoting effects on OS via activation of the SRC/ERK/c-MYC/PFKFB2 pathway. Taken together, the findings reveal a previously unappreciated function of SLIT2/ROBO1 signaling in OS, which is intertwined with metabolic alterations that promote cancer progression. Targeting the SLIT2/ROBO1 axis may be a potential therapeutic approach for patients with OS. |Animals [MESH] |Glycolysis [MESH] |Heterografts [MESH] |Humans [MESH] |Intercellular Signaling Peptides and Proteins/genetics/*metabolism [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Mice, Nude [MESH] |Nerve Tissue Proteins/genetics/*metabolism [MESH] |Osteosarcoma/genetics/*metabolism [MESH] |Oxidative Phosphorylation [MESH] |Phosphofructokinase-2/genetics/*metabolism [MESH] |Proto-Oncogene Proteins c-myc/genetics/*metabolism [MESH] |Receptors, Immunologic/genetics/*metabolism [MESH] |Roundabout Proteins [MESH] |Signal Transduction [MESH] |Slit Homolog 2 Protein [MESH]SLIT2/ROBO1 axis contributes to the Warburg effect in osteosarcoma thr(epmc).pdf DeepDyve Pubget Overpricing