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2008 ; 6
(12
): 904-12
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gab.com Text
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English Wikipedia
Super-shedding and the link between human infection and livestock carriage of
Escherichia coli O157
#MMPMID19008890
Chase-Topping M
; Gally D
; Low C
; Matthews L
; Woolhouse M
Nat Rev Microbiol
2008[Dec]; 6
(12
): 904-12
PMID19008890
show ga
Cattle that excrete more Escherichia coli O157 than others are known as
super-shedders. Super-shedding has important consequences for the epidemiology of
E. coli O157 in cattle--its main reservoir--and for the risk of human infection,
particularly owing to environmental exposure. Ultimately, control measures
targeted at super-shedders may prove to be highly effective. We currently have
only a limited understanding of both the nature and the determinants of
super-shedding. However, super-shedding has been observed to be associated with
colonization at the terminal rectum and might also occur more often with certain
pathogen phage types. More generally, epidemiological evidence suggests that
super-shedding might be important in other bacterial and viral infections.