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10.1534/g3.117.300421 http://scihub22266oqcxt.onion/10.1534/g3.117.300421 C5844311!5844311!29326229     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       G3+(Bethesda) 2018 ; 8 (3): 909-22 Nephropedia Template TP {{tp|p=29326229|t=2018. Genomic Understanding of an Infectious Brain Disease from the Desert |pdf=|usr=}}{{29326229}} gab.com Text Genomic Understanding of an Infectious Brain Disease from the Desert JO: G3 (Bethesda) http://www.kidney.de/pget.php?&tw=1&pmid=29326229 #FOAvip Rhinocladiella mackenziei accounts for the majority of fungal brain infections in the Middle East, and is restricted to the arid climate zone between Saudi Arabia and Pakistan. Neurotropic dissemination caused by this fungus has been reported in immunocompromised, but also immunocompetent individuals. If untreated, the infection is fatal. Outside of humans, the environmental niche of R. mackenziei is unknown, and the fungus has been only cultured from brain biopsies. In this paper, we describe the whole-genome resequencing of two R. mackenziei strains from patients in Saudi Arabia and Qatar. We assessed intraspecies variation and genetic signatures to uncover the genomic basis of the pathogenesis, and potential niche adaptations. We found that the duplicated genes (paralogs) are more susceptible to accumulating significant mutations. Comparative genomics with other filamentous ascomycetes revealed a diverse arsenal of genes likely engaged in pathogenicity, such as the degradation of aromatic compounds and iron acquisition. In addition, intracellular accumulation of trehalose and choline suggests possible adaptations to the conditions of an arid climate region. Specifically, protein family contractions were found, including short-chain dehydrogenase/reductase SDR, the cytochrome P450 (CYP) (E-class), and the G-protein ? WD-40 repeat. Gene composition and metabolic potential indicate extremotolerance and hydrocarbon assimilation, suggesting a possible environmental habitat of oil-polluted desert soil. Twit Text FOAVip Genomic Understanding of an Infectious Brain Disease from the Desert ????G3 (Bethesda) http://www.kidney.de/pget.php?&tw=1&pmid=29326229 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29326229 #FOAvip English Wikipedia <ref>{{Cite pmid|29326229}}</ref> Genomic Understanding of an Infectious Brain Disease from the Desert #MMPMID29326229 Moreno LF; Ahmed AAO; Brankovics B; Cuomo CA; Menken SBJ; Taj-Aldeen SJ; Faidah H; Stielow JB; Teixeira Mde M; Prenafeta-Boldú FX; Vicente VA; de Hoog S G3 (Bethesda) 2018[Mar]; 8 (3): 909-22 PMID29326229show ga Rhinocladiella mackenziei accounts for the majority of fungal brain infections in the Middle East, and is restricted to the arid climate zone between Saudi Arabia and Pakistan. Neurotropic dissemination caused by this fungus has been reported in immunocompromised, but also immunocompetent individuals. If untreated, the infection is fatal. Outside of humans, the environmental niche of R. mackenziei is unknown, and the fungus has been only cultured from brain biopsies. In this paper, we describe the whole-genome resequencing of two R. mackenziei strains from patients in Saudi Arabia and Qatar. We assessed intraspecies variation and genetic signatures to uncover the genomic basis of the pathogenesis, and potential niche adaptations. We found that the duplicated genes (paralogs) are more susceptible to accumulating significant mutations. Comparative genomics with other filamentous ascomycetes revealed a diverse arsenal of genes likely engaged in pathogenicity, such as the degradation of aromatic compounds and iron acquisition. In addition, intracellular accumulation of trehalose and choline suggests possible adaptations to the conditions of an arid climate region. Specifically, protein family contractions were found, including short-chain dehydrogenase/reductase SDR, the cytochrome P450 (CYP) (E-class), and the G-protein ? WD-40 repeat. Gene composition and metabolic potential indicate extremotolerance and hydrocarbon assimilation, suggesting a possible environmental habitat of oil-polluted desert soil. äGenomic Understanding of an Infectious Brain Disease from the Desert (epmc).pdf DeepDyve Pubget Overpricing