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10.1080/20013078.2018.1440131 http://scihub22266oqcxt.onion/10.1080/20013078.2018.1440131 C5844050!5844050!29535849     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Extracell+Vesicles 2018 ; 7 (1): ä Nephropedia Template TP {{tp|p=29535849|t=2018. Extracellular vesicles as a platform for membrane-associated therapeutic protein delivery |pdf=|usr=}}{{29535849}} gab.com Text Extracellular vesicles as a platform for membrane-associated therapeutic protein delivery JO: J Extracell Vesicles http://www.kidney.de/pget.php?&tw=1&pmid=29535849 #FOAvip Membrane proteins are of great research interest, particularly because they are rich in targets for therapeutic application. The suitability of various membrane proteins as targets for therapeutic formulations, such as drugs or antibodies, has been studied in preclinical and clinical studies. For therapeutic application, however, a protein must be expressed and purified in as close to its native conformation as possible. This has proven difficult for membrane proteins, as their native conformation requires the association with an appropriate cellular membrane. One solution to this problem is to use extracellular vesicles as a display platform. Exosomes and microvesicles are membranous extracellular vesicles that are released from most cells. Their membranes may provide a favourable microenvironment for membrane proteins to take on their proper conformation, activity, and membrane distribution; moreover, membrane proteins can cluster into microdomains on the surface of extracellular vesicles following their biogenesis. In this review, we survey the state-of-the-art of extracellular vesicle (exosome and small-sized microvesicle)-based therapeutics, evaluate the current biological understanding of these formulations, and forecast the technical advances that will be needed to continue driving the development of membrane protein therapeutics. Twit Text FOAVip Extracellular vesicles as a platform for membrane-associated therapeutic protein delivery ????J Extracell Vesicles http://www.kidney.de/pget.php?&tw=1&pmid=29535849 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29535849 #FOAvip English Wikipedia <ref>{{Cite pmid|29535849}}</ref> Extracellular vesicles as a platform for membrane-associated therapeutic protein delivery #MMPMID29535849 Yang Y; Hong Y; Cho E; Kim GB; Kim IS J Extracell Vesicles 2018[]; 7 (1): ä PMID29535849show ga Membrane proteins are of great research interest, particularly because they are rich in targets for therapeutic application. The suitability of various membrane proteins as targets for therapeutic formulations, such as drugs or antibodies, has been studied in preclinical and clinical studies. For therapeutic application, however, a protein must be expressed and purified in as close to its native conformation as possible. This has proven difficult for membrane proteins, as their native conformation requires the association with an appropriate cellular membrane. One solution to this problem is to use extracellular vesicles as a display platform. Exosomes and microvesicles are membranous extracellular vesicles that are released from most cells. Their membranes may provide a favourable microenvironment for membrane proteins to take on their proper conformation, activity, and membrane distribution; moreover, membrane proteins can cluster into microdomains on the surface of extracellular vesicles following their biogenesis. In this review, we survey the state-of-the-art of extracellular vesicle (exosome and small-sized microvesicle)-based therapeutics, evaluate the current biological understanding of these formulations, and forecast the technical advances that will be needed to continue driving the development of membrane protein therapeutics. äExtracellular vesicles as a platform for membrane-associated therapeut(epmc).pdf DeepDyve Pubget Overpricing