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10.3892/ol.2018.8067 http://scihub22266oqcxt.onion/10.3892/ol.2018.8067 C5844032!5844032!29556311     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncol+Lett 2018 ; 15 (4): 5841-8 Nephropedia Template TP {{tp|p=29556311|t=2018. MiR-574-5p mediates the cell cycle and apoptosis in thyroid cancer cells via Wnt/?-catenin signaling by repressing the expression of Quaking proteins |pdf=|usr=}}{{29556311}} gab.com Text MiR-574-5p mediates the cell cycle and apoptosis in thyroid cancer cells via Wnt/ -catenin signaling by repressing the expression of Quaking proteins JO: Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=29556311 #FOAvip Thyroid cancer is the most frequently occurring type of endocrine tumor, with a rapidly increasing incidence rate. MicroRNA (miR)-574-5p is a candidate oncogene in various types of cancer. The present study identified that miR-574-5p affected the cell cycle distribution and apoptosis of BCPAP and FTC133 thyroid cancer cells via ?-catenin/Wnt signaling by targeting Quaking proteins (QKIs). An MTT assay demonstrated that the knockdown of miR-574-5p suppressed the proliferation of the thyroid cancer cells. Fluorescence-activated cell sorting analysis demonstrated that the inhibition of miR-574-5p induced the G1/S phase arrest and apoptosis of the cells. Reverse transcription-quantitative polymerase chain reaction and western blot analyses revealed that the knockdown of miR-574-5p significantly upregulated the mRNA and protein expression levels of QKIs. Furthermore, western blot analysis identified that the knockdown of miR-574-5p also repressed the Wnt/?-catenin pathway via downregulating the expression of ?-catenin, cyclin D1 and survivin, and upregulating the phosphorylation of ?-catenin. The further depletion of QKIs in combination with the knockdown of miR-574-5p not only increased the expression of ?-catenin, cyclin D1 and survivin, but also rescued the apoptosis of thyroid cancer cells induced by the miR-574-5p knockdown. In conclusion, these findings indicated that the aberrant upregulation of miR-574-5p may be oncogenic, through regulating the Wnt/?-catenin pathway by targeting QKIs. Twit Text FOAVip MiR-574-5p mediates the cell cycle and apoptosis in thyroid cancer cells via Wnt/ -catenin signaling by repressing the expression of Quaking proteins ????Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=29556311 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29556311 #FOAvip English Wikipedia <ref>{{Cite pmid|29556311}}</ref> MiR-574-5p mediates the cell cycle and apoptosis in thyroid cancer cells via Wnt/?-catenin signaling by repressing the expression of Quaking proteins #MMPMID29556311 Zhang Z; Li X; Xiao Q; Wang Z Oncol Lett 2018[Apr]; 15 (4): 5841-8 PMID29556311show ga Thyroid cancer is the most frequently occurring type of endocrine tumor, with a rapidly increasing incidence rate. MicroRNA (miR)-574-5p is a candidate oncogene in various types of cancer. The present study identified that miR-574-5p affected the cell cycle distribution and apoptosis of BCPAP and FTC133 thyroid cancer cells via ?-catenin/Wnt signaling by targeting Quaking proteins (QKIs). An MTT assay demonstrated that the knockdown of miR-574-5p suppressed the proliferation of the thyroid cancer cells. Fluorescence-activated cell sorting analysis demonstrated that the inhibition of miR-574-5p induced the G1/S phase arrest and apoptosis of the cells. Reverse transcription-quantitative polymerase chain reaction and western blot analyses revealed that the knockdown of miR-574-5p significantly upregulated the mRNA and protein expression levels of QKIs. Furthermore, western blot analysis identified that the knockdown of miR-574-5p also repressed the Wnt/?-catenin pathway via downregulating the expression of ?-catenin, cyclin D1 and survivin, and upregulating the phosphorylation of ?-catenin. The further depletion of QKIs in combination with the knockdown of miR-574-5p not only increased the expression of ?-catenin, cyclin D1 and survivin, but also rescued the apoptosis of thyroid cancer cells induced by the miR-574-5p knockdown. In conclusion, these findings indicated that the aberrant upregulation of miR-574-5p may be oncogenic, through regulating the Wnt/?-catenin pathway by targeting QKIs. äMiR-574-5p mediates the cell cycle and apoptosis in thyroid cancer cel(epmc).pdf DeepDyve Pubget Overpricing