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10.3892/ol.2018.7817 http://scihub22266oqcxt.onion/10.3892/ol.2018.7817 C5843996!5843996!29556289     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29556289&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 500 Internal Server Error in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncol+Lett 2018 ; 15 (4): 4423-6 Nephropedia Template TP {{tp|p=29556289|t=2018. Pro-metastatic signaling of the trans fatty acid elaidic acid is associated with lipid rafts |pdf=|usr=}}{{29556289}} gab.com Text Pro-metastatic signaling of the trans fatty acid elaidic acid is associated with lipid rafts JO: Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=29556289 #FOAvip Trans fatty acids (TFAs) are risk factors for cardiovascular disorders, and the cancer-promoting effects of TFAs have been previously reported. The present study examined the effects and signaling of elaidic acid (EA), a TFA, in colorectal cancer (CRC) cells. Oral intake of EA was found to increase metastasis of HT29 human CRC cells. Results indicated that, in the plasma membrane, EA was integrated into cholesterol rafts, which contain epidermal growth factor receptors (EGFR). EA increased nanog and c-myc, and decreased PGC-1A through lipid raft-associated EGFR signaling in HT29 cells. Depletion of cholesterol by methyl-?-cyclodextrin treatment abrogated the EA-induced stemness and oxidative phosphorylation. Simvastatin treatment also abrogated EA-enhanced tumor growth. These results indicate that EA enhances the stemness by activating EGFR in lipid rafts. Twit Text FOAVip Pro-metastatic signaling of the trans fatty acid elaidic acid is associated with lipid rafts ????Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=29556289 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29556289 #FOAvip English Wikipedia <ref>{{Cite pmid|29556289}}</ref> Pro-metastatic signaling of the trans fatty acid elaidic acid is associated with lipid rafts #MMPMID29556289 Kishi S; Fujiwara-Tani R; Luo Y; Kawahara I; Goto K; Fujii K; Ohmori H; Nakashima C; Sasaki T; Kuniyasu H Oncol Lett 2018[Apr]; 15 (4): 4423-6 PMID29556289show ga Trans fatty acids (TFAs) are risk factors for cardiovascular disorders, and the cancer-promoting effects of TFAs have been previously reported. The present study examined the effects and signaling of elaidic acid (EA), a TFA, in colorectal cancer (CRC) cells. Oral intake of EA was found to increase metastasis of HT29 human CRC cells. Results indicated that, in the plasma membrane, EA was integrated into cholesterol rafts, which contain epidermal growth factor receptors (EGFR). EA increased nanog and c-myc, and decreased PGC-1A through lipid raft-associated EGFR signaling in HT29 cells. Depletion of cholesterol by methyl-?-cyclodextrin treatment abrogated the EA-induced stemness and oxidative phosphorylation. Simvastatin treatment also abrogated EA-enhanced tumor growth. These results indicate that EA enhances the stemness by activating EGFR in lipid rafts. äPro-metastatic signaling of the trans fatty acid elaidic acid is assoc(epmc).pdf DeepDyve Pubget Overpricing