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2016 ; 17
(3
): ä Nephropedia Template TP
gab.com Text
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The association of ACE gene polymorphism with diabetic kidney disease and
renoprotective efficacy of valsartan
#MMPMID27638852
Wang Y
; Peng W
; Zhang X
; Qiao H
; Wang L
; Xu Z
; Wu C
J Renin Angiotensin Aldosterone Syst
2016[Jul]; 17
(3
): ä PMID27638852
show ga
INTRODUCTION: To investigate the associations between the insertion/deletion
(I/D) polymorphisms in the angiotensin converting enzyme (ACE) gene and
susceptibility to diabetic kidney disease (DKD); and the efficacy of valsartan in
reducing the urine protein in Type 2 diabetes mellitus (T2DM) patients. MATERIALS
AND METHODS: We enrolled 128 T2DM patients in this study, including 54 cases with
DKD (DKD+) and 74 controls (DKD-). The ACE polymorphism was assayed by polymerase
chain reaction (PCR), and the genotype distribution and allele frequency were
analyzed. The DKD+ group was subdivided into the DD, ID and II subgroups, based
on their genotypes. In addition, patients with DKD received valsartan treatment
for 12 weeks. We determined changes in the urinary albumin to creatinine ratio
(ACR) and serum creatinine (SCr). RESULTS: The frequencies of the genotypes DD
and ID were higher in the DKD+ than in the DKD- group. The frequency of allele D
was higher, and of allele I was lower, in the DKD+ than in DKD- group (p < 0.05).
Following valsartan treatment, albuminuria was significantly decreased in
subgroups DD and ID (p < 0.05). CONCLUSIONS: In T2DM patients, the ACE I/D
polymorphism was associated with onset of DKD. Furthermore, the ACE I/D
polymorphism influenced the renoprotective response to valsartan: Patients with
the DD genotype benefitted the most from this treatment.
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