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10.1177/1470320317705232 http://scihub22266oqcxt.onion/10.1177/1470320317705232 C5843863!5843863!28490223     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Renin+Angiotensin+Aldosterone+Syst 2017 ; 18 (2): ä Nephropedia Template TP {{tp|p=28490223|t=2017. Molecular remodeling of the renin-angiotensin system after kidney transplantation |pdf=|usr=}}{{28490223}} gab.com Text Molecular remodeling of the renin-angiotensin system after kidney transplantation JO: J Renin Angiotensin Aldosterone Syst http://www.kidney.de/pget.php?&tw=1&pmid=28490223 #FOAvip Objective:: We aimed at assessing the molecular adaptation of the renin-angiotensin system (RAS) after successful kidney transplantation (KTX). Materials and methods:: In this prospective, exploratory study we analyzed 12 hemodialysis (HD) patients, who received a KTX and had excellent graft function six to 12 months thereafter. The concentrations of plasma Angiotensin (Ang) peptides (Ang I, Ang II, Ang-(1?7), Ang-(1?5), Ang-(2?8), Ang-(3?8)) were simultaneously quantified with a novel mass spectrometry-based method. Further, renin and aldosterone concentrations were determined by standard immunoassays. Results:: Ang values showed a strong inter-individual variability among HD patients. Yet, despite a continued broad dispersion of Ang values after KTX, a substantial improvement of the renin/Ang II correlation was observed in patients without RAS blockade or on angiotensin receptor blocker (HD: renin/Ang II R2 = 0.660, KTX: renin/Ang II R2 = 0.918). Ang-(1?7) representing the alternative RAS axis was only marginally detectable both on HD and after KTX. Conclusions:: Following KTX, renin-dependent Ang II formation adapts in non-ACE inhibitor-treated patients. Thus, a largely normal RAS regulation is reconstituted after successful KTX. However, individual Ang concentration variations and a lack of potentially beneficial alternative peptides after KTX call for individualized treatment. The long-term post-transplant RAS regulation remains to be determined. Twit Text FOAVip Molecular remodeling of the renin-angiotensin system after kidney transplantation ????J Renin Angiotensin Aldosterone Syst http://www.kidney.de/pget.php?&tw=1&pmid=28490223 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28490223 #FOAvip English Wikipedia <ref>{{Cite pmid|28490223}}</ref> Molecular remodeling of the renin-angiotensin system after kidney transplantation #MMPMID28490223 Antlanger M; Domenig O; Kovarik JJ; Kaltenecker CC; Kopecky C; Poglitsch M; Säemann MD J Renin Angiotensin Aldosterone Syst 2017[Apr]; 18 (2): ä PMID28490223show ga Objective:: We aimed at assessing the molecular adaptation of the renin-angiotensin system (RAS) after successful kidney transplantation (KTX). Materials and methods:: In this prospective, exploratory study we analyzed 12 hemodialysis (HD) patients, who received a KTX and had excellent graft function six to 12 months thereafter. The concentrations of plasma Angiotensin (Ang) peptides (Ang I, Ang II, Ang-(1?7), Ang-(1?5), Ang-(2?8), Ang-(3?8)) were simultaneously quantified with a novel mass spectrometry-based method. Further, renin and aldosterone concentrations were determined by standard immunoassays. Results:: Ang values showed a strong inter-individual variability among HD patients. Yet, despite a continued broad dispersion of Ang values after KTX, a substantial improvement of the renin/Ang II correlation was observed in patients without RAS blockade or on angiotensin receptor blocker (HD: renin/Ang II R2 = 0.660, KTX: renin/Ang II R2 = 0.918). Ang-(1?7) representing the alternative RAS axis was only marginally detectable both on HD and after KTX. Conclusions:: Following KTX, renin-dependent Ang II formation adapts in non-ACE inhibitor-treated patients. Thus, a largely normal RAS regulation is reconstituted after successful KTX. However, individual Ang concentration variations and a lack of potentially beneficial alternative peptides after KTX call for individualized treatment. The long-term post-transplant RAS regulation remains to be determined. äMolecular remodeling of the renin-angiotensin system after kidney tran(epmc).pdf DeepDyve Pubget Overpricing