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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Renin+Angiotensin+Aldosterone+Syst
2017 ; 18
(1
): 1470320316689338
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Is angiotensin-(3-4) (Val-Tyr), the shortest angiotensin II-derived peptide,
opening new vistas on the renin-angiotensin system?
#MMPMID28097883
Dias J
; Axelband F
; Lara LS
; Muzi-Filho H
; Vieyra A
J Renin Angiotensin Aldosterone Syst
2017[Jan]; 18
(1
): 1470320316689338
PMID28097883
show ga
Angiotensin-(3-4) (Ang-(3-4) or Val-Tyr) is the shorter angiotensin (Ang)
II-derived peptide, formed through successive hydrolysis that culminates with the
release of Val-Tyr as a dipeptide. It is formed both in plasma and in kidney from
Ang II and Ang III, and can be considered a component of the systemic and
organ-based renin-angiotensin system. It is potently antihypertensive in humans
and rats, and its concerted actions on proximal tubule cells culminate in the
inhibition of fluid reabsorption, hyperosmotic urinary excretion of Na(+). At the
renal cell signaling level, Ang-(3-4) counteracts Ang II-type 1 receptor-mediated
responses by acting as an allosteric enhancer in Ang II-type 2 receptor
populations that target adenosine triphosphate-dependent Ca(2+) and Na(+)
transporters through a cyclic adenosine monophosphate-activated protein kinase
pathway.