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10.1177/1470320316689338

http://scihub22266oqcxt.onion/10.1177/1470320316689338
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suck abstract from ncbi


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pmid28097883
      J+Renin+Angiotensin+Aldosterone+Syst 2017 ; 18 (1 ): 1470320316689338
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  • Is angiotensin-(3-4) (Val-Tyr), the shortest angiotensin II-derived peptide, opening new vistas on the renin-angiotensin system? #MMPMID28097883
  • Dias J ; Axelband F ; Lara LS ; Muzi-Filho H ; Vieyra A
  • J Renin Angiotensin Aldosterone Syst 2017[Jan]; 18 (1 ): 1470320316689338 PMID28097883 show ga
  • Angiotensin-(3-4) (Ang-(3-4) or Val-Tyr) is the shorter angiotensin (Ang) II-derived peptide, formed through successive hydrolysis that culminates with the release of Val-Tyr as a dipeptide. It is formed both in plasma and in kidney from Ang II and Ang III, and can be considered a component of the systemic and organ-based renin-angiotensin system. It is potently antihypertensive in humans and rats, and its concerted actions on proximal tubule cells culminate in the inhibition of fluid reabsorption, hyperosmotic urinary excretion of Na(+). At the renal cell signaling level, Ang-(3-4) counteracts Ang II-type 1 receptor-mediated responses by acting as an allosteric enhancer in Ang II-type 2 receptor populations that target adenosine triphosphate-dependent Ca(2+) and Na(+) transporters through a cyclic adenosine monophosphate-activated protein kinase pathway.
  • |*Renin-Angiotensin System [MESH]
  • |Angiotensin II/*metabolism [MESH]
  • |Animals [MESH]
  • |Humans [MESH]
  • |Kidney/drug effects/metabolism [MESH]
  • |Peptides/metabolism [MESH]
  • |Receptor, Angiotensin, Type 1/metabolism [MESH]


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