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10.4274/tjh.2017.0266

http://scihub22266oqcxt.onion/10.4274/tjh.2017.0266
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C5843777!5843777!28753129
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suck abstract from ncbi


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pmid28753129      Turk+J+Haematol 2018 ; 35 (1): 66-70
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  • Glomerular and Tubular Functions in Children and Adults with Transfusion-Dependent Thalassemia #MMPMID28753129
  • Annayev A; Karaka? Z; Karaman S; Yalç?ner A; Y?lmaz A; Emre S
  • Turk J Haematol 2018[Mar]; 35 (1): 66-70 PMID28753129show ga
  • This study aimed at assessing renal functions in patients with transfusion-dependent thalassemia (TDT). Fifty patients and 30 controls were enrolled in this prospective study. Serum levels of electrolytes and albumin were measured by a spectrophotometer. Serum levels of cystatin-C and urinary levels of ?2-microglobulin were measured by nephelometric method. Thirty-eight patients were receiving deferasirox and 8 were on deferiprone. Serum electrolytes and albumin levels of the patients were found to be within normal ranges. Urinary ?2-microglobulin and serum cystatin-C levels were significantly higher in patients than controls. They did not significantly differ between the subgroup of patients on deferiprone and the control group, whereas they were found to be higher in patients using deferasirox compared to controls. Urinary ?2-microglobulin levels significantly increased in patients who were receiving high-dose deferasirox compared to those who were receiving a daily dose of 15-20 mg/kg or controls. Subclinical renal injury may be present in TDT patients.
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