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10.1007/s00018-017-2701-z http://scihub22266oqcxt.onion/10.1007/s00018-017-2701-z C5843667!5843667!29103147     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Mol+Life+Sci 2018 ; 75 (7): 1179-90 Nephropedia Template TP {{tp|p=29103147|t=2018. Master regulatory role of p63 in epidermal development and disease |pdf=|usr=}}{{29103147}} gab.com Text Master regulatory role of p63 in epidermal development and disease JO: Cell Mol Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=29103147 #FOAvip The transcription factor p63 is a master regulator of epidermal development. Mutations in p63 give rise to human developmental diseases that often manifest epidermal defects. In this review, we summarize major p63 isoforms identified so far and p63 mutation-associated human diseases that show epidermal defects. We discuss key roles of p63 in epidermal keratinocyte proliferation and differentiation, emphasizing its master regulatory control of the gene expression pattern and epigenetic landscape that define epidermal fate. We subsequently review the essential function of p63 during epidermal commitment and transdifferentiation towards epithelial lineages, highlighting the notion that p63 is the guardian of the epithelial lineage. Finally, we discuss current therapeutic development strategies for p63 mutation-associated diseases. Our review proposes future directions for dissecting p63-controlled mechanisms in normal and diseased epidermal development and for developing therapeutic options. Twit Text FOAVip Master regulatory role of p63 in epidermal development and disease ????Cell Mol Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=29103147 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29103147 #FOAvip English Wikipedia <ref>{{Cite pmid|29103147}}</ref> Master regulatory role of p63 in epidermal development and disease #MMPMID29103147 Soares E; Zhou H Cell Mol Life Sci 2018[]; 75 (7): 1179-90 PMID29103147show ga The transcription factor p63 is a master regulator of epidermal development. Mutations in p63 give rise to human developmental diseases that often manifest epidermal defects. In this review, we summarize major p63 isoforms identified so far and p63 mutation-associated human diseases that show epidermal defects. We discuss key roles of p63 in epidermal keratinocyte proliferation and differentiation, emphasizing its master regulatory control of the gene expression pattern and epigenetic landscape that define epidermal fate. We subsequently review the essential function of p63 during epidermal commitment and transdifferentiation towards epithelial lineages, highlighting the notion that p63 is the guardian of the epithelial lineage. Finally, we discuss current therapeutic development strategies for p63 mutation-associated diseases. Our review proposes future directions for dissecting p63-controlled mechanisms in normal and diseased epidermal development and for developing therapeutic options. äMaster regulatory role of p63 in epidermal development and disease (epmc).pdf DeepDyve Pubget Overpricing