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10.3892/ijo.2018.4280 http://scihub22266oqcxt.onion/10.3892/ijo.2018.4280 C5843405!5843405!29484374     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Oncol 2018 ; 52 (4): 1081-94 Nephropedia Template TP {{tp|p=29484374|t=2018. The post-translational modification, SUMOylation, and cancer (Review) |pdf=|usr=}}{{29484374}} gab.com Text The post-translational modification, SUMOylation, and cancer (Review) JO: Int J Oncol http://www.kidney.de/pget.php?&tw=1&pmid=29484374 #FOAvip SUMOylation is a reversible post-translational modification which has emerged as a crucial molecular regulatory mechanism, involved in the regulation of DNA damage repair, immune responses, carcinogenesis, cell cycle progression and apoptosis. Four SUMO isoforms have been identified, which are SUMO1, SUMO2/3 and SUMO4. The small ubiquitin-like modifier (SUMO) pathway is conserved in all eukaryotes and plays pivotal roles in the regulation of gene expression, cellular signaling and the maintenance of genomic integrity. The SUMO catalytic cycle includes maturation, activation, conjugation, ligation and de-modification. The dysregulation of the SUMO system is associated with a number of diseases, particularly cancer. SUMOylation is widely involved in carcinogenesis, DNA damage response, cancer cell proliferation, metastasis and apoptosis. SUMO can be used as a potential therapeutic target for cancer. In this review, we briefly outline the basic concepts of the SUMO system and summarize the involvement of SUMO proteins in cancer cells in order to better understand the role of SUMO in human disease. Twit Text FOAVip The post-translational modification, SUMOylation, and cancer (Review) ????Int J Oncol http://www.kidney.de/pget.php?&tw=1&pmid=29484374 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29484374 #FOAvip English Wikipedia <ref>{{Cite pmid|29484374}}</ref> The post-translational modification, SUMOylation, and cancer (Review) #MMPMID29484374 Han ZJ; Feng YH; Gu BH; Li YM; Chen H Int J Oncol 2018[Apr]; 52 (4): 1081-94 PMID29484374show ga SUMOylation is a reversible post-translational modification which has emerged as a crucial molecular regulatory mechanism, involved in the regulation of DNA damage repair, immune responses, carcinogenesis, cell cycle progression and apoptosis. Four SUMO isoforms have been identified, which are SUMO1, SUMO2/3 and SUMO4. The small ubiquitin-like modifier (SUMO) pathway is conserved in all eukaryotes and plays pivotal roles in the regulation of gene expression, cellular signaling and the maintenance of genomic integrity. The SUMO catalytic cycle includes maturation, activation, conjugation, ligation and de-modification. The dysregulation of the SUMO system is associated with a number of diseases, particularly cancer. SUMOylation is widely involved in carcinogenesis, DNA damage response, cancer cell proliferation, metastasis and apoptosis. SUMO can be used as a potential therapeutic target for cancer. In this review, we briefly outline the basic concepts of the SUMO system and summarize the involvement of SUMO proteins in cancer cells in order to better understand the role of SUMO in human disease. äThe post-translational modification, SUMOylation, and cancer (Review) (epmc).pdf DeepDyve Pubget Overpricing