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10.3892/ijo.2018.4287 http://scihub22266oqcxt.onion/10.3892/ijo.2018.4287 C5843392!5843392!29532857     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29532857&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Oncol 2018 ; 52 (4): 1071-80 Nephropedia Template TP {{tp|p=29532857|t=2018. Cutaneous melanoma: From pathogenesis to therapy (Review) |pdf=|usr=}}{{29532857}} gab.com Text Cutaneous melanoma: From pathogenesis to therapy (Review) JO: Int J Oncol http://www.kidney.de/pget.php?&tw=1&pmid=29532857 #FOAvip In less than 10 years, melanoma treatment has been revolutionized with the approval of tyrosine kinase inhibitors and immune checkpoint inhibitors, which have been shown to have a significant impact on the prognosis of patients with melanoma. The early steps of this transformation have taken place in research laboratories. The mitogen-activated protein kinase (MAPK) pathway, phosphoinositol-3-kinase (PI3K) pathway promote the development of melanoma through numerous genomic alterations on different components of these pathways. Moreover, melanoma cells deeply interact with the tumor microenvironment and the immune system. This knowledge has led to the identification of novel therapeutic targets and treatment strategies. In this review, the epidemiological features of cutaneous melanoma along with the biological mechanisms involved in its development and progression are summarized. The current state-of-the-art of advanced stage melanoma treatment strategies and the currently available evidence of the use of predictive and prognostic biomarkers are also discussed. Twit Text FOAVip Cutaneous melanoma: From pathogenesis to therapy (Review) ????Int J Oncol http://www.kidney.de/pget.php?&tw=1&pmid=29532857 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29532857 #FOAvip English Wikipedia <ref>{{Cite pmid|29532857}}</ref> Cutaneous melanoma: From pathogenesis to therapy (Review) #MMPMID29532857 Leonardi GC; Falzone L; Salemi R; Zanghì A; Spandidos DA; McCubrey JA; Candido S; Libra M Int J Oncol 2018[Apr]; 52 (4): 1071-80 PMID29532857show ga In less than 10 years, melanoma treatment has been revolutionized with the approval of tyrosine kinase inhibitors and immune checkpoint inhibitors, which have been shown to have a significant impact on the prognosis of patients with melanoma. The early steps of this transformation have taken place in research laboratories. The mitogen-activated protein kinase (MAPK) pathway, phosphoinositol-3-kinase (PI3K) pathway promote the development of melanoma through numerous genomic alterations on different components of these pathways. Moreover, melanoma cells deeply interact with the tumor microenvironment and the immune system. This knowledge has led to the identification of novel therapeutic targets and treatment strategies. In this review, the epidemiological features of cutaneous melanoma along with the biological mechanisms involved in its development and progression are summarized. The current state-of-the-art of advanced stage melanoma treatment strategies and the currently available evidence of the use of predictive and prognostic biomarkers are also discussed. äCutaneous melanoma: From pathogenesis to therapy (Review) (epmc).pdf DeepDyve Pubget Overpricing