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2018 ; 10
(1
): e2037
Nephropedia Template TP
gab.com Text
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Radiation Necrosis - A Growing Problem in a Case of Brain Metastases Following
Whole Brain Radiotherapy and Stereotactic Radiosurgery
#MMPMID29541558
Song YP
; Colaco RJ
Cureus
2018[Jan]; 10
(1
): e2037
PMID29541558
show ga
Stereotactic radiosurgery (SRS) provides excellent control in the treatment of
brain metastases (BM). The use of newer, targeted and immunotherapy treatments
have resulted in improved overall survival in patients even with an extensive
metastatic disease. Hence, it is increasingly important to consider the potential
for late toxicities like radiation-induced necrosis (RN) of the brain. We present
a case of a patient with stage IV anaplastic lymphoma kinase (ALK) positive
adenocarcinoma of the lung who underwent stereotactic radiosurgery to her brain
metastases and received targeted treatment. While her intracranial and
extracranial disease remained well controlled, we discuss the radiation-induced
necrosis she suffered as a result of the treatment, the related diagnostic
dilemma involved, and the subsequent management of this late toxicity of
stereotactic radiosurgery.