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2016 ; 17
(1
): 455
Nephropedia Template TP
gab.com Text
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English Wikipedia
Southern African guidelines on the safe use of pre-exposure prophylaxis in
persons at risk of acquiring HIV-1 infection
#MMPMID29568613
Bekker LG
; Rebe K
; Venter F
; Maartens G
; Moorhouse M
; Conradie F
; Wallis C
; Black V
; Harley B
; Eakles R
South Afr J HIV Med
2016[]; 17
(1
): 455
PMID29568613
show ga
The Southern African HIV Clinicians Society published its first set of oral
pre-exposure prophylaxis (PrEP) guidelines in June 2012 for men who have sex with
men (MSM) who are at risk of HIV infection. With the flurry of data that has been
generated in PrEP clinical research since the first guideline, it became evident
that there was a need to revise and expand the PrEP guidelines with new evidence
of safety and efficacy of PrEP in several populations, including MSM, transgender
persons, heterosexual men and women, HIV-serodiscordant couples and people who
inject drugs. This need is particularly relevant following the World Health
Organization (WHO) Consolidated Treatment Guidelines released in September 2015.
These guidelines advise that PrEP is a highly effective, safe, biomedical option
for HIV prevention that can be incorporated with other combination prevention
strategies in Southern Africa, given the high prevalence of HIV in the region.
PrEP should be tailored to populations at highest risk of HIV acquisition, whilst
further data from studies in the region accrue to guide optimal deployment to
realise the greatest impact regionally. PrEP may be used intermittently during
periods of perceived HIV acquisition risk, rather than continually and lifelong,
as is the case with antiretroviral treatment. Recognition and accurate
measurement of potential risk in individuals and populations also warrants
discussion, but are not extensively covered in these guidelines.
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