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10.1038/s41590-017-0035-5 http://scihub22266oqcxt.onion/10.1038/s41590-017-0035-5 C5842895!5842895!29358707     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Immunol 2018 ; 19 (3): 267-78 Nephropedia Template TP {{tp|p=29358707|t=2018. The RNA binding protein PTBP1 is necessary for B cell selection in germinal centers |pdf=|usr=}}{{29358707}} gab.com Text The RNA binding protein PTBP1 is necessary for B cell selection in germinal centers JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29358707 #FOAvip Antibody affinity maturation occurs in germinal centres (GC) where B cells cycle between the light zone (LZ) and the dark zone. In the LZ GC B cells bearing immunoglobulins with the highest affinity for antigen receive positive selection signals from T helper cells that promotes their rapid proliferation. Here we show that the RNA binding protein PTBP1 is necessary for the progression of GC B cells through late S-phase of the cell cycle and for affinity maturation. PTBP1 is required for the proper expression of the c-MYC-dependent gene program induced in GC B cells receiving T cell help and directly regulates the alternative splicing and abundance of transcripts increased during positive selection to promote proliferation. Twit Text FOAVip The RNA binding protein PTBP1 is necessary for B cell selection in germinal centers ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29358707 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29358707 #FOAvip English Wikipedia <ref>{{Cite pmid|29358707}}</ref> The RNA binding protein PTBP1 is necessary for B cell selection in germinal centers #MMPMID29358707 Monzón-Casanova E; Screen M; Díaz-Muñoz MD; Coulson RMR; Bell SE; Lamers G; Solimena M; Smith CW; Turner M Nat Immunol 2018[Mar]; 19 (3): 267-78 PMID29358707show ga Antibody affinity maturation occurs in germinal centres (GC) where B cells cycle between the light zone (LZ) and the dark zone. In the LZ GC B cells bearing immunoglobulins with the highest affinity for antigen receive positive selection signals from T helper cells that promotes their rapid proliferation. Here we show that the RNA binding protein PTBP1 is necessary for the progression of GC B cells through late S-phase of the cell cycle and for affinity maturation. PTBP1 is required for the proper expression of the c-MYC-dependent gene program induced in GC B cells receiving T cell help and directly regulates the alternative splicing and abundance of transcripts increased during positive selection to promote proliferation. äThe RNA binding protein PTBP1 is necessary for B cell selection in ger(epmc).pdf DeepDyve Pubget Overpricing