Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29514670
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Antihypertensive drugs use and the risk of prostate cancer: a meta-analysis of 21
observational studies
#MMPMID29514670
Cao L
; Zhang S
; Jia CM
; He W
; Wu LT
; Li YQ
; Wang W
; Li Z
; Ma J
BMC Urol
2018[Mar]; 18
(1
): 17
PMID29514670
show ga
BACKGROUND: Due to the lack of strong evidence to identify the relationship
between antihypertensive drugs use and the risk of prostate cancer, it was needed
to do a systematic review to go into the subject. METHODS: We systematically
searched PubMed, Web of Science and Embase to identify studies published, through
May 2015. Two evaluators independently reviewed and selected articles involving
the subject. We used the Newcastle-Ottawa Scale (NOS) to assess the quality of
the studies. All extracted results to evaluate the relationship between
antihypertensive drugs usage and prostate cancer risk were pool-analysed using
Stata 12.0 software. RESULTS: A total of 12 cohort and 9 case-control studies
were ultimately included in our review. Most of the studies were evaluated to be
of high quality. There was no significant relationship between angiotensin
converting enzyme inhibitors (ACEI) usage and the risk of prostate cancer (RR
1.07, 95% CI 0.96-1.20), according to the total pool-analysed. Use of angiotensin
receptor blocker (ARB) was not associated with the risk of prostate cancer (RR
1.09, 95% CI 0.97-1.21), while use of CCB may well increase prostate cancer risk
based on the total pool-analysed (RR 1.08, 95% CI 1-1.16). Moreover, subgroup
analysis suggested that use of CCB clearly increased prostate cancer risk (RR
1.10, 95% CI 1.04-1.16) in terms of case-control studies. There was also no
significant relationship between use of diuretic (RR 1.09, 95% CI 0.95-1.25) or
antiadrenergic agents (RR 1.22, 95% CI 0.76-1.96) and prostate cancer risk.
CONCLUSIONS: There is no significant relationship between the use of
antihypertensive drugs (ACEI, ARB, beta-blockers and diuretics) and prostate
cancer risk, but CCB may well increase prostate cancer risk, according to
existing observational studies.
|Antihypertensive Agents/adverse effects/*therapeutic use
[MESH]
|Calcium Channel Blockers/*adverse effects/therapeutic use
[MESH]
free
free
free
