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2018 ; 19
(1
): 54
Nephropedia Template TP
gab.com Text
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English Wikipedia
Belimumab and low-doses of mycophenolate mofetil as induction therapy of class IV
lupus nephritis: case series and literature review
#MMPMID29514612
Margiotta DPE
; Basta F
; Batani V
; Afeltra A
BMC Nephrol
2018[Mar]; 19
(1
): 54
PMID29514612
show ga
BACKGROUND: The treatment of Lupus Nephritis (LN) is an unmet need in the
management of patients with Systemic Lupus Erythematosus (SLE). CASE PRESENTATION
: We report two cases of women affected by Lupus Nephritis (LN) ISN/RNP Class IV
with serological active disease, high disease activity and marked fatigue. In
both cases, Mycophenolate mofetil (MMF), as induction therapy, was poorly
tolerated because of gastrointestinal toxicity. Belimumab, together with
low-doses of MMF, was effective as induction treatment leading to early
achievement of complete renal response in these two selected cases of LN.
CONCLUSIONS: We also report a literature review concerning the efficacy and
safety of Belimumab in Lupus Nephritis. Further studies are needed to evaluate
the use of Belimumab to manage the renal involvement in patients with Systemic
Lupus Erythematosus, waiting for the results of ongoing randomized clinical
trials.