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10.1183/16000617.0094-2017 http://scihub22266oqcxt.onion/10.1183/16000617.0094-2017 C5842433!5842433!29263174     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+Respir+Rev 2017 ; 26 (146): ä Nephropedia Template TP {{tp|p=29263174|t=2017. Metabolic dysfunction in pulmonary hypertension: from basic science to clinical practice |pdf=|usr=}}{{29263174}} gab.com Text Metabolic dysfunction in pulmonary hypertension: from basic science to clinical practice JO: Eur Respir Rev http://www.kidney.de/pget.php?&tw=1&pmid=29263174 #FOAvip Pulmonary hypertension (PH) is an often-fatal vascular disease of unclear molecular origins. The pulmonary vascular remodelling which occurs in PH is characterised by elevated vasomotor tone and a pro-proliferative state, ultimately leading to right ventricular dysfunction and heart failure. Guided in many respects by prior evidence from cancer biology, recent investigations have identified metabolic aberrations as crucial components of the disease process in both the pulmonary vessels and the right ventricle. Given the need for improved diagnostic and therapeutic options for PH, the development or repurposing of metabolic tracers and medications could provide an effective avenue for preventing or even reversing disease progression. In this review, we describe the metabolic mechanisms that are known to be dysregulated in PH; we explore the advancing diagnostic testing and imaging modalities that are being developed to improve diagnostic capability for this disease; and we discuss emerging drugs for PH which target these metabolic pathways. Twit Text FOAVip Metabolic dysfunction in pulmonary hypertension: from basic science to clinical practice ????Eur Respir Rev http://www.kidney.de/pget.php?&tw=1&pmid=29263174 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29263174 #FOAvip English Wikipedia <ref>{{Cite pmid|29263174}}</ref> Metabolic dysfunction in pulmonary hypertension: from basic science to clinical practice #MMPMID29263174 Chan SY; Rubin LJ Eur Respir Rev 2017[Dec]; 26 (146): ä PMID29263174show ga Pulmonary hypertension (PH) is an often-fatal vascular disease of unclear molecular origins. The pulmonary vascular remodelling which occurs in PH is characterised by elevated vasomotor tone and a pro-proliferative state, ultimately leading to right ventricular dysfunction and heart failure. Guided in many respects by prior evidence from cancer biology, recent investigations have identified metabolic aberrations as crucial components of the disease process in both the pulmonary vessels and the right ventricle. Given the need for improved diagnostic and therapeutic options for PH, the development or repurposing of metabolic tracers and medications could provide an effective avenue for preventing or even reversing disease progression. In this review, we describe the metabolic mechanisms that are known to be dysregulated in PH; we explore the advancing diagnostic testing and imaging modalities that are being developed to improve diagnostic capability for this disease; and we discuss emerging drugs for PH which target these metabolic pathways. äMetabolic dysfunction in pulmonary hypertension: from basic science to(epmc).pdf DeepDyve Pubget Overpricing