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10.1093/emph/eoy005

http://scihub22266oqcxt.onion/10.1093/emph/eoy005
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C5842392!5842392!29588855
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suck abstract from ncbi


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pmid29588855      Evol+Med+Public+Health 2018 ; 2018 (1): 60-6
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  • Phage treatment of an aortic graft infected with Pseudomonas aeruginosa #MMPMID29588855
  • Chan BK; Turner PE; Kim S; Mojibian HR; Elefteriades JA; Narayan D
  • Evol Med Public Health 2018[]; 2018 (1): 60-6 PMID29588855show ga
  • Management of prosthetic vascular graft infections caused by Pseudomonas aeruginosa can be a significant challenge to clinicians. These infections often do not resolve with antibiotic therapy alone due to antibiotic resistance/tolerance by bacteria, poor ability of antibiotics to permeate/reduce biofilms and/or other factors. Bacteriophage OMKO1 binding to efflux pump proteins in P. aeruginosa was consistent with an evolutionary trade-off: wildtype bacteria were killed by phage whereas evolution of phage-resistance led to increased antibiotic sensitivity. However, phage clinical-use has not been demonstrated. Here, we present a case report detailing therapeutic application of phage OMKO1 to treat a chronic P. aeruginosa infection of an aortic Dacron graft with associated aorto-cutaneous fistula. Following a single application of phage OMKO1 and ceftazidime, the infection appeared to resolve with no signs of recurrence.
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