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2018 ; 11
(ä): 51-55
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Long non-coding RNA ANRIL is associated with a poor prognosis of osteosarcoma and
promotes tumorigenesis via PI3K/Akt pathway
#MMPMID29520337
Yu G
; Liu G
; Yuan D
; Dai J
; Cui Y
; Tang X
J Bone Oncol
2018[Jun]; 11
(ä): 51-55
PMID29520337
show ga
AIM: Increasing evidence has shown that long noncoding RNAs (lncRNAs) ANRIL may
function as oncogenes in various types of malignancies. However, there is still a
lack of knowledge concerning its role in osteosarcoma (OS). In this study, we
aimed to investigate the influence of ANRIL on cell proliferation and invasion of
OS and to determine its association with clinicopathological features of the
patients. METHODS: The tumor specimens and the adjacent normal tissues were
collected from 57 OS patients and the expression level of ANRIL was quantified by
RT-qPCR. High expression of ANRIL was defined as a relative mRNA expression of
>?1.5 fold (tumor/normal). Knockdown of ANRIL was performed in human OS cell
lines to investigate its influence on cell proliferation, apoptosis and invasion.
In addition, expression of downstream genes in the transfected cells were
determined by Western blot. RESULTS: The expression level of ANRIL was
significantly increased in OS tissues than in the adjacent normal tissues. 33
patients were included in the high expression group and the other 24 patients
were included in the normal expression group. ANRIL expression was significantly
associated with tumor size (5.7?cm?±?2.4?cm vs. 4.3?cm?±?1.7?cm, p?=?0.02) and
the 5-year survival rate (51.5% vs. 79.1%, p?=?0.03). Knockdown of ANRIL could
significantly induce cell apoptosis and inhibit cell proliferation and invasion.
Moreover, knockdown of ANRIL could significantly decrease the expression level of
phosphorylated PI3K and AKT in OS cells. CONCLUSIONS: Upregulated expression of
ANRIL is associated with the tumor development and prognosis of OS. ANRIL may
regulate the function of OS cells through the AKT pathway.
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