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2018 ; 12
(1
): 281-287
Nephropedia Template TP
gab.com Text
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English Wikipedia
Galectin-3 regulation of wound healing and fibrotic processes: insights for
chronic skin wound therapeutics
#MMPMID29372416
McLeod K
; Walker JT
; Hamilton DW
J Cell Commun Signal
2018[Mar]; 12
(1
): 281-287
PMID29372416
show ga
A member of the lectin family, galectin-3 is a 250 amino-acid protein that
contains a C-terminus carbohydrate recognition domain (CRD) that recognizes
?-galactosides. Considered to have certain common properties associated with
matricellular proteins, galectin-3 is expressed in the dermis and epidermis in
healthy skin and is upregulated in skin healing, peaking at day 1 post wounding
in mice. Galectin-3 has been implicated in several processes central to the wound
healing response, specifically in the regulation of inflammation, macrophage
polarization, angiogenesis, fibroblast to myofibroblast transition and
re-epithelialization. However, it appears that many of the effects of Galectin-3
are highly tissue specific and context dependent. Genetic deletion of galectin-3
shows different effects in skin compared to lung, heart, and kidney remodeling.
In this review, we will compare galectin-3 functions in these tissues.
Furthermore, we will discuss, based on its identified regulation of cell
processes, whether in an exogenous form, galectin-3 could represent a novel
therapeutic for impaired skin healing.