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10.1007/s12079-017-0433-3 http://scihub22266oqcxt.onion/10.1007/s12079-017-0433-3 C5842194!5842194!29264709     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cell+Commun+Signal 2018 ; 12 (1): 171-9 Nephropedia Template TP {{tp|p=29264709|t=2018. Integration of pro- and anti-angiogenic signals by endothelial cells |pdf=|usr=}}{{29264709}} gab.com Text Integration of pro- and anti-angiogenic signals by endothelial cells JO: J Cell Commun Signal http://www.kidney.de/pget.php?&tw=1&pmid=29264709 #FOAvip Angiogenesis or neovascularization is a complex multi-step physiological process that occurs throughout life both in normal tissues and in disease. It is tightly regulated by the balance between pro-angiogenic and anti-angiogenic factors. The angiogenic switch has been identified as the key step during tumor progression in which the balance between pro-angiogenic and anti-angiogenic factors leans toward pro-angiogenic stimuli promoting the progression of tumors from dormancy to dysplasia and ultimately malignancy. This event can be described as either the outcome of a genetic event occurring in cancer cells themselves, or the positive and negative cross-talk between tumor-associated endothelial cells and other cellular components of the tumor microenvironment. In recent years, the mechanisms underlying the angiogenic switch have been extensively investigated in particular to identify therapeutic targets that can lead to development of effective therapies. In this review, we will discuss the current findings on the regulatory pathways in endothelial cells that are involved in the angiogenic switch with an emphasis on the role of anti-angiogenic protein, thrombospondin-1 (TSP-1) and pro-angiogenic factor, vascular endothelial growth factor (VEGF). Twit Text FOAVip Integration of pro- and anti-angiogenic signals by endothelial cells ????J Cell Commun Signal http://www.kidney.de/pget.php?&tw=1&pmid=29264709 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29264709 #FOAvip English Wikipedia <ref>{{Cite pmid|29264709}}</ref> Integration of pro- and anti-angiogenic signals by endothelial cells #MMPMID29264709 Kazerounian S; Lawler J J Cell Commun Signal 2018[Mar]; 12 (1): 171-9 PMID29264709show ga Angiogenesis or neovascularization is a complex multi-step physiological process that occurs throughout life both in normal tissues and in disease. It is tightly regulated by the balance between pro-angiogenic and anti-angiogenic factors. The angiogenic switch has been identified as the key step during tumor progression in which the balance between pro-angiogenic and anti-angiogenic factors leans toward pro-angiogenic stimuli promoting the progression of tumors from dormancy to dysplasia and ultimately malignancy. This event can be described as either the outcome of a genetic event occurring in cancer cells themselves, or the positive and negative cross-talk between tumor-associated endothelial cells and other cellular components of the tumor microenvironment. In recent years, the mechanisms underlying the angiogenic switch have been extensively investigated in particular to identify therapeutic targets that can lead to development of effective therapies. In this review, we will discuss the current findings on the regulatory pathways in endothelial cells that are involved in the angiogenic switch with an emphasis on the role of anti-angiogenic protein, thrombospondin-1 (TSP-1) and pro-angiogenic factor, vascular endothelial growth factor (VEGF). äIntegration of pro- and anti-angiogenic signals by endothelial cells (epmc).pdf DeepDyve Pubget Overpricing