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10.1007/s12079-017-0429-z http://scihub22266oqcxt.onion/10.1007/s12079-017-0429-z C5842191!5842191!29170885     free     free     free       J+Cell+Commun+Signal 2018 ; 12 (1): 319-31 Nephropedia Template TP {{tp|p=29170885|t=2018. The structure of the S-layer of Clostridium difficile |pdf=|usr=}}{{29170885}} gab.com Text The structure of the S-layer of Clostridium difficile JO: J Cell Commun Signal http://www.kidney.de/pget.php?&tw=1&pmid=29170885 #FOAvip The nosocomially acquired pathogen Clostridium difficile is the primary causative agent of antibiotic associated diarrhoea and causes tens of thousands of deaths globally each year. C. difficile presents a paracrystalline protein array on the surface of the cell known as an S-layer. S-layers have been demonstrated to possess a wide range of important functions, which, combined with their inherent accessibility, makes them a promising drug target. The unusually complex S-layer of C. difficile is primarily comprised of the high- and low- molecular weight S-layer proteins, HMW SLP and LMW SLP, formed from the cleavage of the S-layer precursor protein, SlpA, but may also contain up to 28 SlpA paralogues. A model of how the S-layer functions as a whole is required if it is to be exploited in fighting the bacterium. Here, we provide a summary of what is known about the S-layer of C. difficile and each of the paralogues and, considering some of the domains present, suggest potential roles for them. Twit Text FOAVip The structure of the S-layer of Clostridium difficile ????J Cell Commun Signal http://www.kidney.de/pget.php?&tw=1&pmid=29170885 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29170885 #FOAvip English Wikipedia <ref>{{Cite pmid|29170885}}</ref> The structure of the S-layer of Clostridium difficile #MMPMID29170885 Bradshaw WJ; Roberts AK; Shone CC; Acharya KR J Cell Commun Signal 2018[Mar]; 12 (1): 319-31 PMID29170885show ga The nosocomially acquired pathogen Clostridium difficile is the primary causative agent of antibiotic associated diarrhoea and causes tens of thousands of deaths globally each year. C. difficile presents a paracrystalline protein array on the surface of the cell known as an S-layer. S-layers have been demonstrated to possess a wide range of important functions, which, combined with their inherent accessibility, makes them a promising drug target. The unusually complex S-layer of C. difficile is primarily comprised of the high- and low- molecular weight S-layer proteins, HMW SLP and LMW SLP, formed from the cleavage of the S-layer precursor protein, SlpA, but may also contain up to 28 SlpA paralogues. A model of how the S-layer functions as a whole is required if it is to be exploited in fighting the bacterium. Here, we provide a summary of what is known about the S-layer of C. difficile and each of the paralogues and, considering some of the domains present, suggest potential roles for them. äThe structure of the S-layer of Clostridium difficile (epmc).pdf DeepDyve Pubget Overpricing