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10.1172/jci.insight.92232 http://scihub22266oqcxt.onion/10.1172/jci.insight.92232 C5841864!5841864 !28978805     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28978805 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       JCI+Insight 2017 ; 2 (19 ): ä Nephropedia Template TP {{tp|p=28978805 |t=2017. Fibroblast activation protein augments progression and metastasis of pancreatic ductal adenocarcinoma |pdf=|usr=}}{{28978805 }} gab.com Text Fibroblast activation protein augments progression and metastasis of pancreatic ductal adenocarcinoma JO: JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=28978805 #FOAvip Pancreatic ductal adenocarcinomas (PDAs) are desmoplastic and can undergo epithelial-to-mesenchymal transition to confer metastasis and chemoresistance. Studies have demonstrated that phenotypically and functionally distinct stromal cell populations exist in PDAs. Fibroblast activation protein-expressing (FAP-expressing) cells act to enhance PDA progression, while ?-smooth muscle actin myofibroblasts can restrain PDA. Thus, identification of precise molecular targets that mediate the protumorigenic activity of FAP+ cells will guide development of therapy for PDA. Herein, we demonstrate that FAP overexpression in the tumor microenvironment correlates with poor overall and disease-free survival of PDA patients. Genetic deletion of FAP delayed onset of primary tumor and prolonged survival of mice in the KPC mouse model of PDA. While genetic deletion of FAP did not affect primary tumor weight in advanced disease, FAP deficiency increased tumor necrosis and impeded metastasis to multiple organs. Lineage-tracing studies unexpectedly showed that FAP is not only expressed by stromal cells, but can also be detected in a subset of CD90+ mesenchymal PDA cells, representing up to 20% of total intratumoral FAP+ cells. These data suggest that FAP may regulate PDA progression and metastasis in cell-autonomous and/or non-cell-autonomous fashions. Together, these data support pursuing FAP as a therapeutic target in PDA. Twit Text FOAVip Fibroblast activation protein augments progression and metastasis of pancreatic ductal adenocarcinoma ????JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=28978805 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28978805 #FOAvip English Wikipedia <ref>{{Cite pmid|28978805 }}</ref> Fibroblast activation protein augments progression and metastasis of pancreatic ductal adenocarcinoma #MMPMID28978805 Lo A ; Li CP ; Buza EL ; Blomberg R ; Govindaraju P ; Avery D ; Monslow J ; Hsiao M ; Puré E JCI Insight 2017[Oct]; 2 (19 ): ä PMID28978805 show ga Pancreatic ductal adenocarcinomas (PDAs) are desmoplastic and can undergo epithelial-to-mesenchymal transition to confer metastasis and chemoresistance. Studies have demonstrated that phenotypically and functionally distinct stromal cell populations exist in PDAs. Fibroblast activation protein-expressing (FAP-expressing) cells act to enhance PDA progression, while ?-smooth muscle actin myofibroblasts can restrain PDA. Thus, identification of precise molecular targets that mediate the protumorigenic activity of FAP+ cells will guide development of therapy for PDA. Herein, we demonstrate that FAP overexpression in the tumor microenvironment correlates with poor overall and disease-free survival of PDA patients. Genetic deletion of FAP delayed onset of primary tumor and prolonged survival of mice in the KPC mouse model of PDA. While genetic deletion of FAP did not affect primary tumor weight in advanced disease, FAP deficiency increased tumor necrosis and impeded metastasis to multiple organs. Lineage-tracing studies unexpectedly showed that FAP is not only expressed by stromal cells, but can also be detected in a subset of CD90+ mesenchymal PDA cells, representing up to 20% of total intratumoral FAP+ cells. These data suggest that FAP may regulate PDA progression and metastasis in cell-autonomous and/or non-cell-autonomous fashions. Together, these data support pursuing FAP as a therapeutic target in PDA. |Adult [MESH] |Aged [MESH] |Aged, 80 and over [MESH] |Animals [MESH] |Biomarkers, Tumor/metabolism/*physiology [MESH] |Carcinoma, Pancreatic Ductal/metabolism/*pathology/*secondary [MESH] |Disease Progression [MESH] |Endopeptidases [MESH] |Female [MESH] |Gelatinases/deficiency/metabolism/*physiology [MESH] |Heterografts [MESH] |Humans [MESH] |Kaplan-Meier Estimate [MESH] |Male [MESH] |Membrane Proteins/deficiency/metabolism/*physiology [MESH] |Mice, Knockout [MESH] |Middle Aged [MESH] |Neoplasm Transplantation [MESH] |Pancreatic Neoplasms/metabolism/*pathology [MESH] |Serine Endopeptidases/deficiency/metabolism/*physiology [MESH]Fibroblast activation protein augments progression and metastasis of p(epmc).pdf DeepDyve Pubget Overpricing