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10.1177/1470320315625703 http://scihub22266oqcxt.onion/10.1177/1470320315625703 C5841570!5841570 !27009282     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27009282 &cmd=llinks): Failed to open stream: HTTP request failed! 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Evaluation of the (1-24) adrenocorticotropin stimulation test for the diagnosis of primary aldosteronism |pdf=|usr=}}{{27009282 }} gab.com Text Evaluation of the (1-24) adrenocorticotropin stimulation test for the diagnosis of primary aldosteronism JO: J Renin Angiotensin Aldosterone Syst http://www.kidney.de/pget.php?&tw=1&pmid=27009282 #FOAvip OBJECTIVE: The purpose of this study was to investigate the diagnostic power of the adrenocorticotropin (ACTH) stimulation test in patients with primary aldosteronism (PA) and those with aldosterone-producing adenoma (APA). DESIGN: This study was based on a retrospective database analysis. SUBJECTS AND METHODS: We assessed 158 hypertensive patients with a high plasma aldosterone-to-renin ratio (ARR) including 97 with at least one positive confirmatory test result who did not undergo surgery and comprised a "possible PA" group, 19 with negative results in all tests who were the "non-PA" group, and 41 diagnosed with APA following surgery who were the APA group. The "confirmed PA group" included APA patients and patients from the possible PA group showing both high ARR and hypokalemia. One case was diagnosed as a metastasis. RESULTS: Receiver-operating characteristic (ROC) analysis showed that the diagnostic accuracy of ACTH test was not very effective in differentiating between APA patients and possible PA and non-PA patients. The optimal cut-off value of maximal plasma aldosterone concentration for differentiating between patient in the confirmed PA group and other patients showed moderate accuracy. CONCLUSIONS: The ACTH test may not be useful as a screening or confirmatory test, but the test may be useful for differentiating between patients with confirmed PA and the rest of the cohort. The positive finding of the ACTH test may at least support a higher likelihood of lateralizing on adrenal venous sampling. Twit Text FOAVip Evaluation of the (1-24) adrenocorticotropin stimulation test for the diagnosis of primary aldosteronism ????J Renin Angiotensin Aldosterone Syst http://www.kidney.de/pget.php?&tw=1&pmid=27009282 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27009282 #FOAvip English Wikipedia <ref>{{Cite pmid|27009282 }}</ref> Evaluation of the (1-24) adrenocorticotropin stimulation test for the diagnosis of primary aldosteronism #MMPMID27009282 Terui K ; Kageyama K ; Nigawara T ; Moriyama T ; Sakihara S ; Takayasu S ; Tsushima Y ; Watanki Y ; Yamagata S ; Sugiyama A ; Murasawa S ; Nakada Y ; Suda T ; Daimon M J Renin Angiotensin Aldosterone Syst 2016[Jan]; 17 (1 ): 1470320315625703 PMID27009282 show ga OBJECTIVE: The purpose of this study was to investigate the diagnostic power of the adrenocorticotropin (ACTH) stimulation test in patients with primary aldosteronism (PA) and those with aldosterone-producing adenoma (APA). DESIGN: This study was based on a retrospective database analysis. SUBJECTS AND METHODS: We assessed 158 hypertensive patients with a high plasma aldosterone-to-renin ratio (ARR) including 97 with at least one positive confirmatory test result who did not undergo surgery and comprised a "possible PA" group, 19 with negative results in all tests who were the "non-PA" group, and 41 diagnosed with APA following surgery who were the APA group. The "confirmed PA group" included APA patients and patients from the possible PA group showing both high ARR and hypokalemia. One case was diagnosed as a metastasis. RESULTS: Receiver-operating characteristic (ROC) analysis showed that the diagnostic accuracy of ACTH test was not very effective in differentiating between APA patients and possible PA and non-PA patients. The optimal cut-off value of maximal plasma aldosterone concentration for differentiating between patient in the confirmed PA group and other patients showed moderate accuracy. CONCLUSIONS: The ACTH test may not be useful as a screening or confirmatory test, but the test may be useful for differentiating between patients with confirmed PA and the rest of the cohort. The positive finding of the ACTH test may at least support a higher likelihood of lateralizing on adrenal venous sampling. |*Reagent Kits, Diagnostic [MESH] |Adrenocorticotropic Hormone/*pharmacology [MESH] |Aldosterone/blood [MESH] |Humans [MESH] |Hydrocortisone/blood [MESH] |Hyperaldosteronism/blood/*diagnosis [MESH] |Middle Aged [MESH] |ROC Curve [MESH]Evaluation of the (1-24) adrenocorticotropin stimulation test for the (epmc).pdf DeepDyve Pubget Overpricing