Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.3892/ol.2018.7989 http://scihub22266oqcxt.onion/10.3892/ol.2018.7989 C5840749!5840749!29552180     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncol+Lett 2018 ; 15 (4): 5368-74 Nephropedia Template TP {{tp|p=29552180|t=2018. SIRT6 inhibits colorectal cancer stem cell proliferation by targeting CDC25A |pdf=|usr=}}{{29552180}} gab.com Text SIRT6 inhibits colorectal cancer stem cell proliferation by targeting CDC25A JO: Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=29552180 #FOAvip Silent information regulator 6 (SIRT6) is broadly considered as a tumor suppressor due to its function in the suppression of oncogene expression. However, the role of SIRT6 in colorectal cancer stem cells (CSCs) remains uncharacterized. In the present study, it was demonstrated that SIRT6 expression was reduced in colorectal CSCs. Overexpression of SIRT6 in colorectal CSCs did not induce cell apoptosis. However, SIRT6 significantly inhibited cell proliferation, colony formation and induced G0/G1 phase arrest in colorectal CSCs. In addition, SIRT6 repressed the expression of cell division cycle 25A (CDC25A), an oncogenic phosphatase. Chromatin immunoprecipitation experiments indicated that SIRT6 directly bound to the CDC25A promoter and decreased the acetylation level of histone H3 lysine 9. Altogether, these data indicated that SIRT6 inhibits colorectal cancer stem cell proliferation by targeting CDC25A. Twit Text FOAVip SIRT6 inhibits colorectal cancer stem cell proliferation by targeting CDC25A ????Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=29552180 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29552180 #FOAvip English Wikipedia <ref>{{Cite pmid|29552180}}</ref> SIRT6 inhibits colorectal cancer stem cell proliferation by targeting CDC25A #MMPMID29552180 Liu W; Wu M; Du H; Shi X; Zhang T; Li J Oncol Lett 2018[Apr]; 15 (4): 5368-74 PMID29552180show ga Silent information regulator 6 (SIRT6) is broadly considered as a tumor suppressor due to its function in the suppression of oncogene expression. However, the role of SIRT6 in colorectal cancer stem cells (CSCs) remains uncharacterized. In the present study, it was demonstrated that SIRT6 expression was reduced in colorectal CSCs. Overexpression of SIRT6 in colorectal CSCs did not induce cell apoptosis. However, SIRT6 significantly inhibited cell proliferation, colony formation and induced G0/G1 phase arrest in colorectal CSCs. In addition, SIRT6 repressed the expression of cell division cycle 25A (CDC25A), an oncogenic phosphatase. Chromatin immunoprecipitation experiments indicated that SIRT6 directly bound to the CDC25A promoter and decreased the acetylation level of histone H3 lysine 9. Altogether, these data indicated that SIRT6 inhibits colorectal cancer stem cell proliferation by targeting CDC25A. äSIRT6 inhibits colorectal cancer stem cell proliferation by targeting (epmc).pdf DeepDyve Pubget Overpricing