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10.3892/ol.2018.7988 http://scihub22266oqcxt.onion/10.3892/ol.2018.7988 C5840714!5840714!29552121     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncol+Lett 2018 ; 15 (4): 4821-6 Nephropedia Template TP {{tp|p=29552121|t=2018. Curcumin inhibits hepatocellular carcinoma growth by targeting VEGF expression |pdf=|usr=}}{{29552121}} gab.com Text Curcumin inhibits hepatocellular carcinoma growth by targeting VEGF expression JO: Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=29552121 #FOAvip Morbidity and mortality owing to hepatocellular carcinoma (HCC), the most common primary liver cancer, has increased in recent years. Curcumin is a polyphenol compound that has been demonstrated to exert effective antiangiogenic, anti-inflammatory, antioxidant, and antitumor effects. However, its clinical effects in HCC remain elusive. The main aim of the present study was to determine the antiangiogenic effects of curcumin in HCC. H22HCC cells were treated with different concentrations of curcumin in vitro. In addition, a mouse xenograft model was used and analyzed for expression levels of vascular endothelial growth factor (VEGF) protein and proteins of the phosphoinositide 3-kinase (PI3K)/AKT serine/threonine kinase 1 (AKT) signaling pathway. Curcumin treatment inhibited H22 cell proliferation and promoted H22 cell apoptosis in a dose-dependent manner in vitro. In addition, curcumin treatment inhibited tumor growth in vivo at the concentrations of 50 and 100 mg/kg. Furthermore, curcumin treatment significantly decreased VEGF expression and PI3K/AKT signaling. The present findings demonstrated that curcumin inhibited HCC proliferation in vitro and in vivo by reducing VEGF expression. Twit Text FOAVip Curcumin inhibits hepatocellular carcinoma growth by targeting VEGF expression ????Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=29552121 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29552121 #FOAvip English Wikipedia <ref>{{Cite pmid|29552121}}</ref> Curcumin inhibits hepatocellular carcinoma growth by targeting VEGF expression #MMPMID29552121 Pan Z; Zhuang J; Ji C; Cai Z; Liao W; Huang Z Oncol Lett 2018[Apr]; 15 (4): 4821-6 PMID29552121show ga Morbidity and mortality owing to hepatocellular carcinoma (HCC), the most common primary liver cancer, has increased in recent years. Curcumin is a polyphenol compound that has been demonstrated to exert effective antiangiogenic, anti-inflammatory, antioxidant, and antitumor effects. However, its clinical effects in HCC remain elusive. The main aim of the present study was to determine the antiangiogenic effects of curcumin in HCC. H22HCC cells were treated with different concentrations of curcumin in vitro. In addition, a mouse xenograft model was used and analyzed for expression levels of vascular endothelial growth factor (VEGF) protein and proteins of the phosphoinositide 3-kinase (PI3K)/AKT serine/threonine kinase 1 (AKT) signaling pathway. Curcumin treatment inhibited H22 cell proliferation and promoted H22 cell apoptosis in a dose-dependent manner in vitro. In addition, curcumin treatment inhibited tumor growth in vivo at the concentrations of 50 and 100 mg/kg. Furthermore, curcumin treatment significantly decreased VEGF expression and PI3K/AKT signaling. The present findings demonstrated that curcumin inhibited HCC proliferation in vitro and in vivo by reducing VEGF expression. äCurcumin inhibits hepatocellular carcinoma growth by targeting VEGF ex(epmc).pdf DeepDyve Pubget Overpricing