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Expression of factors and key components associated with the PI3K signaling
pathway in colon cancer
#MMPMID29552187
Chen H
; Gao J
; Du Z
; Zhang X
; Yang F
; Gao W
Oncol Lett
2018[Apr]; 15
(4
): 5465-5472
PMID29552187
show ga
The pathophysiology of colorectal cancer (CRC) has not been fully elucidated. The
dysregulation of the phosphatidylinositol 3-kinase (PI3K) signaling pathway
frequently contributes to the tumorigenesis and progression of human cancer. The
aim of the present study was to explore the expression and clinical significance
of a number of associated factors and key components of the PI3K signaling
pathway, including phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic
subunit ? (p110?), phosphorylated protein kinase B (p-Akt) Ser473, p-mammalian
target of rapamycin (mTOR) Ser2448, cyclin D1, cyclin dependent kinase (CDK)4,
RELA proto-oncogene, nuclear factor-?? subunit (p65), Ras and extracellular
signal-regulated kinase (ERK)1/2 in human CRC. The expression of target proteins
was detected using immunohistochemistry (IHC) in 65 CRC cases and 15 colonic
adenoma cases. The association between the expression of target proteins and
clinical pathological parameters was analyzed using a ?(2) test. IHC results
revealed that the expression of all target proteins was significantly increased
in CRC tissues compared with in colonic adenoma tissues (P<0.05). No significant
associations were observed between the expression of p110?, p-Akt Ser473, p-mTOR
Ser2448 and sex, age, differentiation, lymph node metastasis or
Tumor-Node-Metastasis staging (P>0.05). Cyclin D1, CDK4 and Ras were revealed to
be expressed significantly higher in poorly differentiated CRC compared with
moderately differentiated CRC (P<0.05). Expression of p65 and ERK1/2 were
significantly increased in cancer tissues with lymph node metastasis compared
with cancer tissues without lymph node metastasis (P<0.05). These results suggest
that the target proteins may all participate in the tumorigenesis of CRC.
Furthermore, cyclin D1, CDK4, Ras, p65 and ERK1/2 may be important in the
progression of CRC. The results of the present study may provide novel predictive
factors and therapeutic targets for CRC.
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