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10.1155/2017/3159798 http://scihub22266oqcxt.onion/10.1155/2017/3159798 C5840678!5840678!29675430     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29675430.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Diabetes+Res 2017 ; 2017 (ä): ä Nephropedia Template TP {{tp|p=29675430|t=2017. Pirfenidone Accelerates Wound Healing in Chronic Diabetic Foot Ulcers: A Randomized, Double-Blind Controlled Trial |pdf=|usr=}}{{29675430}} gab.com Text Pirfenidone Accelerates Wound Healing in Chronic Diabetic Foot Ulcers: A Randomized, Double-Blind Controlled Trial JO: J Diabetes Res http://www.kidney.de/pget.php?&tw=1&pmid=29675430 #FOAvip Background: Diabetic foot ulcers are one disabling complication of diabetes mellitus. Pirfenidone (PFD) is a potent modulator of extracellular matrix. Modified diallyl disulfide oxide (M-DDO) is an antimicrobial and antiseptic agent. Aim: To evaluate efficacy of topical PFD?+?M-DDO in a randomized, double-blind trial versus ketanserin in the treatment of noninfected chronic DFU. Methods: Patients received PFD?+?M-DDO or ketanserin for 6 months. Relative ulcer volume (RUV) was measured every month; biopsies were taken at baseline and months 1 and 2 for histopathology and gene expression analysis for COL-1?, COL-4, KGF, VEGF, ACTA2 (?-SMA), elastin, fibronectin, TGF-?1, TGF-?3, HIF-1?, and HIF-1?. Results: Reduction of median RUV in the PFD?+?M-DDO group was 62%, 89.8%, and 99.7% at months 1?3 and 100% from months 4 to 6. Ketanserin reduced RUV in 38.4%, 56%, 60.8%, 94%, 94.8%, and 100% from the first to the sixth month, respectively. Healing score improved 4.5 points with PFD?+?M-DDO and 1.5 points with ketanserin compared to basal value. Histology analysis revealed few inflammatory cells and organized/ordered collagen fiber bundles in PFD?+?M-DDO. Expression of most genes was increased with PFD?+?M-DDO; 43.8% of ulcers were resolved using PFD?+?M-DDO and 23.5% with ketanserin. Conclusion: PFD?+?M-DDO was more effective than ketanserin in RUV reduction. Twit Text FOAVip Pirfenidone Accelerates Wound Healing in Chronic Diabetic Foot Ulcers: A Randomized, Double-Blind Controlled Trial ????J Diabetes Res http://www.kidney.de/pget.php?&tw=1&pmid=29675430 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29675430 #FOAvip English Wikipedia <ref>{{Cite pmid|29675430}}</ref> Pirfenidone Accelerates Wound Healing in Chronic Diabetic Foot Ulcers: A Randomized, Double-Blind Controlled Trial #MMPMID29675430 Gasca-Lozano LE; Lucano-Landeros S; Ruiz-Mercado H; Salazar-Montes A; Sandoval-Rodríguez A; Garcia-Bañuelos J; Santos-Garcia A; Davila-Rodriguez JR; Navarro-Partida J; Bojórquez-Sepúlveda H; Castañeda-Gomez J; Domínguez-Rosales J; Ruiz-Arcos MA; Sánchez-Parada MG; Armendariz-Borunda J J Diabetes Res 2017[]; 2017 (ä): ä PMID29675430show ga Background: Diabetic foot ulcers are one disabling complication of diabetes mellitus. Pirfenidone (PFD) is a potent modulator of extracellular matrix. Modified diallyl disulfide oxide (M-DDO) is an antimicrobial and antiseptic agent. Aim: To evaluate efficacy of topical PFD?+?M-DDO in a randomized, double-blind trial versus ketanserin in the treatment of noninfected chronic DFU. Methods: Patients received PFD?+?M-DDO or ketanserin for 6 months. Relative ulcer volume (RUV) was measured every month; biopsies were taken at baseline and months 1 and 2 for histopathology and gene expression analysis for COL-1?, COL-4, KGF, VEGF, ACTA2 (?-SMA), elastin, fibronectin, TGF-?1, TGF-?3, HIF-1?, and HIF-1?. Results: Reduction of median RUV in the PFD?+?M-DDO group was 62%, 89.8%, and 99.7% at months 1?3 and 100% from months 4 to 6. Ketanserin reduced RUV in 38.4%, 56%, 60.8%, 94%, 94.8%, and 100% from the first to the sixth month, respectively. Healing score improved 4.5 points with PFD?+?M-DDO and 1.5 points with ketanserin compared to basal value. Histology analysis revealed few inflammatory cells and organized/ordered collagen fiber bundles in PFD?+?M-DDO. Expression of most genes was increased with PFD?+?M-DDO; 43.8% of ulcers were resolved using PFD?+?M-DDO and 23.5% with ketanserin. Conclusion: PFD?+?M-DDO was more effective than ketanserin in RUV reduction. äPirfenidone Accelerates Wound Healing in Chronic Diabetic Foot Ulcers:(epmc).pdf DeepDyve Pubget Overpricing