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10.3892/ol.2018.8047 http://scihub22266oqcxt.onion/10.3892/ol.2018.8047 C5840675!5840675!29552221     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncol+Lett 2018 ; 15 (4): 5903-9 Nephropedia Template TP {{tp|p=29552221|t=2018. TGF-?1 mediates the effects of aspirin on colonic tumor cell proliferation and apoptosis |pdf=|usr=}}{{29552221}} gab.com Text TGF- 1 mediates the effects of aspirin on colonic tumor cell proliferation and apoptosis JO: Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=29552221 #FOAvip Previous studies have demonstrated that aspirin serves an important role in chemoprevention and the suppression of colorectal cancer (CRC); however, the underlying mechanisms for this inhibition by aspirin remain unclear. Aspirin is capable of promoting apoptosis through prostaglandin-dependent orprostaglandin-independent signaling pathways. In the prostaglandin-dependent pathways, inhibition of cyclooxygenase (COX), particularly COX-2, is the primary mechanism known to be involved in aspirin-induced CRC suppression. Previous studies have implicated prostaglandin-independent signaling pathways and certain associated proteins, including SOX7, in aspirin-induced CRC suppression. In the present study, a newly-characterized association between aspirin, transforming growth factor (TGF)-?1 and CRC inhibition was identified. Specifically, aspirin triggers CRC cell apoptosis by inducing the secretion of TGF-?1, and the increased TGF-?1 then leads to apoptosis and proliferation inhibition in CRC cells. Twit Text FOAVip TGF- 1 mediates the effects of aspirin on colonic tumor cell proliferation and apoptosis ????Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=29552221 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29552221 #FOAvip English Wikipedia <ref>{{Cite pmid|29552221}}</ref> TGF-?1 mediates the effects of aspirin on colonic tumor cell proliferation and apoptosis #MMPMID29552221 Wang Y; Du C; Zhang N; Li M; Liu Y; Zhao M; Wang F; Luo F Oncol Lett 2018[Apr]; 15 (4): 5903-9 PMID29552221show ga Previous studies have demonstrated that aspirin serves an important role in chemoprevention and the suppression of colorectal cancer (CRC); however, the underlying mechanisms for this inhibition by aspirin remain unclear. Aspirin is capable of promoting apoptosis through prostaglandin-dependent orprostaglandin-independent signaling pathways. In the prostaglandin-dependent pathways, inhibition of cyclooxygenase (COX), particularly COX-2, is the primary mechanism known to be involved in aspirin-induced CRC suppression. Previous studies have implicated prostaglandin-independent signaling pathways and certain associated proteins, including SOX7, in aspirin-induced CRC suppression. In the present study, a newly-characterized association between aspirin, transforming growth factor (TGF)-?1 and CRC inhibition was identified. Specifically, aspirin triggers CRC cell apoptosis by inducing the secretion of TGF-?1, and the increased TGF-?1 then leads to apoptosis and proliferation inhibition in CRC cells. äTGF-?1 mediates the effects of aspirin on colonic tumor cell prolifera(epmc).pdf DeepDyve Pubget Overpricing