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10.3892/ol.2018.8008 http://scihub22266oqcxt.onion/10.3892/ol.2018.8008 C5840551!5840551 !29552194     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29552194 &cmd=llinks): Failed to open stream: HTTP request failed! 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Activation of hedgehog signaling and its association with cisplatin resistance in ovarian epithelial tumors |pdf=|usr=}}{{29552194 }} gab.com Text Activation of hedgehog signaling and its association with cisplatin resistance in ovarian epithelial tumors JO: Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=29552194 #FOAvip Few studies have evaluated Hedgehog (Hh) signaling pathway activation in different types of ovarian tumors including benign, borderline and malignant ovarian tumors. The present study investigated the expression of Hh signaling pathway components (SHH, SMO, PTCH, and GLI1) in 193 ovarian epithelial tumor specimens (including 147 malignant epithelial ovarian cancers, 30 borderline ovarian tumors, 16 benign ovarian epithelial tumors) and 11 normal ovarian epithelial tissues by immunohistochemistry. The results demonstrated widespread expression of Hh pathway molecules in ovarian tumors. However, there was no significant difference in the expression intensity of SHH among the four groups (P>0.05). Statistically significant differences were identified in the expression intensity of the SMO, PICH and GLI1 among groups (P<0.001). In addition, significant differences were also revealed in the expression levels of SMO (P=0.013) and GLI1 (P=0.0005) between the platinum drug-sensitive and drug-resistant groups. The overexpression of SMO and GLI1 was further confirmed in the cisplatin-resistant ovarian cancer cell line A2780/DDP by immunofluorescence, flow cytometry and western blotting. The results revealed that the Hh pathway components SMO, PICH and GLI1 are activated in ovarian epithelial tumors. Novel potential associations between cisplatin resistance and the overexpression of SMO and Gli1 in malignant epithelial ovarian cancer were also observed, which may provide an innovative approach to the treatment of drug resistant ovarian epithelial cancer. Twit Text FOAVip Activation of hedgehog signaling and its association with cisplatin resistance in ovarian epithelial tumors ????Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=29552194 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29552194 #FOAvip English Wikipedia <ref>{{Cite pmid|29552194 }}</ref> Activation of hedgehog signaling and its association with cisplatin resistance in ovarian epithelial tumors #MMPMID29552194 Song X ; Yan L ; Lu C ; Zhang C ; Zhu F ; Yang J ; Jing H ; Zhang Y ; Qiao J ; Guo H Oncol Lett 2018[Apr]; 15 (4 ): 5569-5576 PMID29552194 show ga Few studies have evaluated Hedgehog (Hh) signaling pathway activation in different types of ovarian tumors including benign, borderline and malignant ovarian tumors. The present study investigated the expression of Hh signaling pathway components (SHH, SMO, PTCH, and GLI1) in 193 ovarian epithelial tumor specimens (including 147 malignant epithelial ovarian cancers, 30 borderline ovarian tumors, 16 benign ovarian epithelial tumors) and 11 normal ovarian epithelial tissues by immunohistochemistry. The results demonstrated widespread expression of Hh pathway molecules in ovarian tumors. However, there was no significant difference in the expression intensity of SHH among the four groups (P>0.05). Statistically significant differences were identified in the expression intensity of the SMO, PICH and GLI1 among groups (P<0.001). In addition, significant differences were also revealed in the expression levels of SMO (P=0.013) and GLI1 (P=0.0005) between the platinum drug-sensitive and drug-resistant groups. The overexpression of SMO and GLI1 was further confirmed in the cisplatin-resistant ovarian cancer cell line A2780/DDP by immunofluorescence, flow cytometry and western blotting. The results revealed that the Hh pathway components SMO, PICH and GLI1 are activated in ovarian epithelial tumors. Novel potential associations between cisplatin resistance and the overexpression of SMO and Gli1 in malignant epithelial ovarian cancer were also observed, which may provide an innovative approach to the treatment of drug resistant ovarian epithelial cancer. äActivation of hedgehog signaling and its association with cisplatin re(epmc).pdf DeepDyve Pubget Overpricing