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10.15252/emmm.201808879 http://scihub22266oqcxt.onion/10.15252/emmm.201808879 C5840544!5840544!29363490     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+Mol+Med 2018 ; 10 (3): ä Nephropedia Template TP {{tp|p=29363490|t=2018. Dissecting human antibody responses: useful, basic and surprising findings |pdf=|usr=}}{{29363490}} gab.com Text Dissecting human antibody responses: useful, basic and surprising findings JO: EMBO Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=29363490 #FOAvip Human memory B cells and plasma cells represent a rich source of antibodies that have been selected in response to human pathogens. In the last decade, different methods have been developed to interrogate the human memory repertoire and isolate monoclonal antibodies. I will discuss how a target?agnostic approach based on high?throughput screening of antibodies produced by cultured B cells and plasma cells has not only provided potent and broadly neutralizing antibodies against a range of pathogens, but has also advanced our understanding of basic aspects of the immune response, from host?pathogen interaction to the role of somatic mutations in affinity maturation and in the diversification of the antibody response. Most surprisingly, this approach has also revealed a new mechanism of diversification based on templated insertion of non?Ig DNA into antibody genes that we discovered in the context of the immune response to malaria infection. Twit Text FOAVip Dissecting human antibody responses: useful, basic and surprising findings ????EMBO Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=29363490 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29363490 #FOAvip English Wikipedia <ref>{{Cite pmid|29363490}}</ref> Dissecting human antibody responses: useful, basic and surprising findings #MMPMID29363490 Lanzavecchia A EMBO Mol Med 2018[Mar]; 10 (3): ä PMID29363490show ga Human memory B cells and plasma cells represent a rich source of antibodies that have been selected in response to human pathogens. In the last decade, different methods have been developed to interrogate the human memory repertoire and isolate monoclonal antibodies. I will discuss how a target?agnostic approach based on high?throughput screening of antibodies produced by cultured B cells and plasma cells has not only provided potent and broadly neutralizing antibodies against a range of pathogens, but has also advanced our understanding of basic aspects of the immune response, from host?pathogen interaction to the role of somatic mutations in affinity maturation and in the diversification of the antibody response. Most surprisingly, this approach has also revealed a new mechanism of diversification based on templated insertion of non?Ig DNA into antibody genes that we discovered in the context of the immune response to malaria infection. äDissecting human antibody responses: useful, basic and surprising find(epmc).pdf DeepDyve Pubget Overpricing