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10.1002/jor.23822 http://scihub22266oqcxt.onion/10.1002/jor.23822 C5840038!5840038 !29194736     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29194736 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       J+Orthop+Res 2018 ; 36 (1 ): 33-51 Nephropedia Template TP {{tp|p=29194736 |t=2018. MicroRNAs in orthopaedic research: Disease associations, potential therapeutic applications, and perspectives |pdf=|usr=}}{{29194736 }} gab.com Text MicroRNAs in orthopaedic research: Disease associations, potential therapeutic applications, and perspectives JO: J Orthop Res http://www.kidney.de/pget.php?&tw=1&pmid=29194736 #FOAvip MicroRNAs (miRNAs) are small non-coding RNAs that function to control many cellular processes by their ability to suppress expression of specific target genes. Tens to hundreds of target genes may be affected by one miRNA, thereby resulting in modulation of multiple pathways in any given cell type. Therefore, altered expression of miRNAs (i.e., during tissue development or in scenarios of disease or cellular stress) can have a profound impact on processes regulating cell differentiation, metabolism, proliferation, or apoptosis, for example. Over the past 5-10 years, thousands of reports have been published on miRNAs in cartilage and bone biology or disease, thus highlighting the significance of these non-coding RNAs in regulating skeletal development and homeostasis. For the purpose of this review, we will focus on miRNAs or miRNA families that have demonstrated function in vivo within the context of cartilage, bone or other orthopaedic-related tissues (excluding muscle). Specifically, we will discuss studies that have utilized miRNA transgenic mouse models or in vivo approaches to target a miRNA with the aim of altering conditions such as osteoarthritis, osteoporosis and bone fractures in rodents. We will not discuss miRNAs in the context skeletal cancers since this topic is worthy of a review of its own. Overall, we aim to provide a comprehensive description of where the field currently stands with respect to the therapeutic potential of specific miRNAs to treat orthopaedic conditions and current technologies to target and modify miRNA function in vivo. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:33-51, 2018. Twit Text FOAVip MicroRNAs in orthopaedic research: Disease associations, potential therapeutic applications, and perspectives ????J Orthop Res http://www.kidney.de/pget.php?&tw=1&pmid=29194736 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29194736 #FOAvip English Wikipedia <ref>{{Cite pmid|29194736 }}</ref> MicroRNAs in orthopaedic research: Disease associations, potential therapeutic applications, and perspectives #MMPMID29194736 McAlinden A ; Im GI J Orthop Res 2018[Jan]; 36 (1 ): 33-51 PMID29194736 show ga MicroRNAs (miRNAs) are small non-coding RNAs that function to control many cellular processes by their ability to suppress expression of specific target genes. Tens to hundreds of target genes may be affected by one miRNA, thereby resulting in modulation of multiple pathways in any given cell type. Therefore, altered expression of miRNAs (i.e., during tissue development or in scenarios of disease or cellular stress) can have a profound impact on processes regulating cell differentiation, metabolism, proliferation, or apoptosis, for example. Over the past 5-10 years, thousands of reports have been published on miRNAs in cartilage and bone biology or disease, thus highlighting the significance of these non-coding RNAs in regulating skeletal development and homeostasis. For the purpose of this review, we will focus on miRNAs or miRNA families that have demonstrated function in vivo within the context of cartilage, bone or other orthopaedic-related tissues (excluding muscle). Specifically, we will discuss studies that have utilized miRNA transgenic mouse models or in vivo approaches to target a miRNA with the aim of altering conditions such as osteoarthritis, osteoporosis and bone fractures in rodents. We will not discuss miRNAs in the context skeletal cancers since this topic is worthy of a review of its own. Overall, we aim to provide a comprehensive description of where the field currently stands with respect to the therapeutic potential of specific miRNAs to treat orthopaedic conditions and current technologies to target and modify miRNA function in vivo. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:33-51, 2018. |*Orthopedics [MESH] |Animals [MESH] |Bone Development [MESH] |Bone Diseases/etiology [MESH] |Homeostasis [MESH] |Humans [MESH] |Mice [MESH]MicroRNAs in orthopaedic research: Disease associations, potential the(epmc).pdf DeepDyve Pubget Overpricing