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10.3889/oamjms.2018.080

http://scihub22266oqcxt.onion/10.3889/oamjms.2018.080
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C5839437!5839437!29531593
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suck abstract from ncbi


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pmid29531593      Open+Access+Maced+J+Med+Sci 2018 ; 6 (2): 303-9
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  • CD33+ HLA-DR? Myeloid-Derived Suppressor Cells Are Increased in Frequency in the Peripheral Blood of Type1 Diabetes Patients with Predominance of CD14+ Subset #MMPMID29531593
  • Hassan M; Raslan HM; Eldin HG; Mahmoud E; Elwajed HAeA
  • Open Access Maced J Med Sci 2018[Feb]; 6 (2): 303-9 PMID29531593show ga
  • INTRODUCTION:: Type 1 Diabetes Mellitus (T1D) is an autoimmune disease that results from the destruction of insulin-producing beta cells of the pancreas by autoreactive T cells. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells that can potently suppress T cell responses. AIM:: To detect the presence of MDSCs in T1D and compare their percentage in T1D versus healthy individuals. METHOD:: Thirty T1D patients were included in the study. Diabetic patients with nephropathy (n = 18) and diabetic patients without nephropathy (n = 12). A control group of healthy individuals (n = 30) were also included. CD33+ and HLA-DR? markers were used to identify MDSCs by flow cytometry. CD14 positive and negative MDSCs subsets were also identified. RESULTS:: MDSCs was significantly increased in T1D than the control group and diabetic patient with nephropathy compared to diabetic patients without nephropathy. M-MDSCs (CD14+ CD33+ HLA?DR?) were the most abundant MDSCs subpopulation in all groups, however their percentage decrease in T1D than the control group. CONCLUSION:: MDSCs are increased in the peripheral blood of T1D with a predominance of the CD14+ MDSCs subset. Future studies are needed to test the immune suppression function of MDSCs in T1D.
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