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10.1016/j.ehj.2016.05.001 http://scihub22266oqcxt.onion/10.1016/j.ehj.2016.05.001 C5839365!5839365!29622954     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Egypt+Heart+J 2017 ; 69 (1): 45-54 Nephropedia Template TP {{tp|p=29622954|t=2017. Predictors of intravenous amiodarone induced liver injury |pdf=|usr=}}{{29622954}} gab.com Text Predictors of intravenous amiodarone induced liver injury JO: Egypt Heart J http://www.kidney.de/pget.php?&tw=1&pmid=29622954 #FOAvip Background: Intravenous (IV) amiodarone may be associated with liver injury that may necessitate drug discontinuation. The prediction of amiodarone induced liver injury (AILI) and its severity may help careful patient monitoring or the choice of other measures alternative to amiodarone in high risk patients. Little is known regarding predictors of AILI. Objectives: To address the predictors of AILI and its severity. Methods: The study included 180 patients indicated for IV amiodarone therapy who were divided into 2 groups: cases (90 patients) who developed AILI, and controls (90 patients) who did not develop AILI. AILI was defined as aminotransferase (ALT and AST) elevation by ?2 folds of baseline levels. Severe AILI was defined as enzyme elevation by >5 folds of baseline values. Results: Multivariate analysis showed that the presence of cardiomyopathy (P = 0.032), congestive hepatomegaly (P = 0.001), increasing baseline total bilirubin (P < 0.0001), direct current cardioversion (P = 0.015), and increasing dose of amiodarone (P = 0.014) to be independent predictors for AILI. Regarding severity of AILI, inotropic support (P = 0.034), congestive hepatomegaly (P = 0.012), increasing baseline total bilirubin (P = 0.001), and increasing dose of amiodarone (P = 0.002) were found to be independent predictors for severe AILI. Among cases, linear regression analysis showed that baseline ALT was the only significant independent predictor of post-amiodarone ALT (P < 0.0001), while baseline AST (P < 0.0001) and EF (P = 0.012) were the only significant independent predictors of post-amiodarone AST. Conclusions: Compromised cardiac, hepatic, and hemodynamic conditions, with increasing dose of IV amiodarone were associated with AILI. Severity of liver injury had linear relationship with baseline aminotransferase levels and left ventricular systolic function. Twit Text FOAVip Predictors of intravenous amiodarone induced liver injury ????Egypt Heart J http://www.kidney.de/pget.php?&tw=1&pmid=29622954 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29622954 #FOAvip English Wikipedia <ref>{{Cite pmid|29622954}}</ref> Predictors of intravenous amiodarone induced liver injury #MMPMID29622954 Diab O; Kamel J; Abd-Elhamid AA Egypt Heart J 2017[Mar]; 69 (1): 45-54 PMID29622954show ga Background: Intravenous (IV) amiodarone may be associated with liver injury that may necessitate drug discontinuation. The prediction of amiodarone induced liver injury (AILI) and its severity may help careful patient monitoring or the choice of other measures alternative to amiodarone in high risk patients. Little is known regarding predictors of AILI. Objectives: To address the predictors of AILI and its severity. Methods: The study included 180 patients indicated for IV amiodarone therapy who were divided into 2 groups: cases (90 patients) who developed AILI, and controls (90 patients) who did not develop AILI. AILI was defined as aminotransferase (ALT and AST) elevation by ?2 folds of baseline levels. Severe AILI was defined as enzyme elevation by >5 folds of baseline values. Results: Multivariate analysis showed that the presence of cardiomyopathy (P = 0.032), congestive hepatomegaly (P = 0.001), increasing baseline total bilirubin (P < 0.0001), direct current cardioversion (P = 0.015), and increasing dose of amiodarone (P = 0.014) to be independent predictors for AILI. Regarding severity of AILI, inotropic support (P = 0.034), congestive hepatomegaly (P = 0.012), increasing baseline total bilirubin (P = 0.001), and increasing dose of amiodarone (P = 0.002) were found to be independent predictors for severe AILI. Among cases, linear regression analysis showed that baseline ALT was the only significant independent predictor of post-amiodarone ALT (P < 0.0001), while baseline AST (P < 0.0001) and EF (P = 0.012) were the only significant independent predictors of post-amiodarone AST. Conclusions: Compromised cardiac, hepatic, and hemodynamic conditions, with increasing dose of IV amiodarone were associated with AILI. Severity of liver injury had linear relationship with baseline aminotransferase levels and left ventricular systolic function. äPredictors of intravenous amiodarone induced liver injury (epmc).pdf DeepDyve Pubget Overpricing