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10.3389/fimmu.2018.00383 http://scihub22266oqcxt.onion/10.3389/fimmu.2018.00383 C5839092!5839092 !29545800     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29545800 &cmd=llinks): Failed to open stream: HTTP request failed! 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Dietary Fiber Pectin Directly Blocks Toll-Like Receptor 2-1 and Prevents Doxorubicin-Induced Ileitis |pdf=|usr=}}{{29545800 }} gab.com Text Dietary Fiber Pectin Directly Blocks Toll-Like Receptor 2-1 and Prevents Doxorubicin-Induced Ileitis JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29545800 #FOAvip Dietary carbohydrate fibers are known to prevent immunological diseases common in Western countries such as allergy and asthma but the underlying mechanisms are largely unknown. Until now beneficial effects of dietary fibers are mainly attributed to fermentation products of the fibers such as anti-inflammatory short-chain fatty acids (SCFAs). Here, we found and present a new mechanism by which dietary fibers can be anti-inflammatory: a commonly consumed fiber, pectin, blocks innate immune receptors. We show that pectin binds and inhibits, toll-like receptor 2 (TLR2) and specifically inhibits the proinflammatory TLR2-TLR1 pathway while the tolerogenic TLR2-TLR6 pathway remains unaltered. This effect is most pronounced with pectins having a low degree of methyl esterification (DM). Low-DM pectin interacts with TLR2 through electrostatic forces between non-esterified galacturonic acids on the pectin and positive charges on the TLR2 ectodomain, as confirmed by testing pectin binding on mutated TLR2. The anti-inflammatory effect of low-DM pectins was first studied in human dendritic cells and mouse macrophages in vitro and was subsequently tested in vivo in TLR2-dependent ileitis in a mouse model. In these mice, ileitis was prevented by pectin administration. Protective effects were shown to be TLR2-TLR1 dependent and independent of the SCFAs produced by the gut microbiota. These data suggest that low-DM pectins as a source of dietary fiber can reduce inflammation through direct interaction with TLR2-TLR1 receptors. Twit Text FOAVip Dietary Fiber Pectin Directly Blocks Toll-Like Receptor 2-1 and Prevents Doxorubicin-Induced Ileitis ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29545800 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29545800 #FOAvip English Wikipedia <ref>{{Cite pmid|29545800 }}</ref> Dietary Fiber Pectin Directly Blocks Toll-Like Receptor 2-1 and Prevents Doxorubicin-Induced Ileitis #MMPMID29545800 Sahasrabudhe NM ; Beukema M ; Tian L ; Troost B ; Scholte J ; Bruininx E ; Bruggeman G ; van den Berg M ; Scheurink A ; Schols HA ; Faas MM ; de Vos P Front Immunol 2018[]; 9 (ä): 383 PMID29545800 show ga Dietary carbohydrate fibers are known to prevent immunological diseases common in Western countries such as allergy and asthma but the underlying mechanisms are largely unknown. Until now beneficial effects of dietary fibers are mainly attributed to fermentation products of the fibers such as anti-inflammatory short-chain fatty acids (SCFAs). Here, we found and present a new mechanism by which dietary fibers can be anti-inflammatory: a commonly consumed fiber, pectin, blocks innate immune receptors. We show that pectin binds and inhibits, toll-like receptor 2 (TLR2) and specifically inhibits the proinflammatory TLR2-TLR1 pathway while the tolerogenic TLR2-TLR6 pathway remains unaltered. This effect is most pronounced with pectins having a low degree of methyl esterification (DM). Low-DM pectin interacts with TLR2 through electrostatic forces between non-esterified galacturonic acids on the pectin and positive charges on the TLR2 ectodomain, as confirmed by testing pectin binding on mutated TLR2. The anti-inflammatory effect of low-DM pectins was first studied in human dendritic cells and mouse macrophages in vitro and was subsequently tested in vivo in TLR2-dependent ileitis in a mouse model. In these mice, ileitis was prevented by pectin administration. Protective effects were shown to be TLR2-TLR1 dependent and independent of the SCFAs produced by the gut microbiota. These data suggest that low-DM pectins as a source of dietary fiber can reduce inflammation through direct interaction with TLR2-TLR1 receptors. |Animals [MESH] |Diet, Western [MESH] |Dietary Fiber/*therapeutic use [MESH] |Disease Models, Animal [MESH] |Doxorubicin [MESH] |Esterification [MESH] |Fatty Acids, Volatile [MESH] |Female [MESH] |HEK293 Cells [MESH] |Hexuronic Acids/chemistry [MESH] |Humans [MESH] |Ileitis/chemically induced/*therapy [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Pectins/chemistry/*therapeutic use [MESH] |Signal Transduction/drug effects [MESH] |Toll-Like Receptor 1/genetics/*metabolism [MESH]Dietary Fiber Pectin Directly Blocks Toll-Like Receptor 2-1 and Preven(epmc).pdf DeepDyve Pubget Overpricing