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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 BMC+Nephrol
2018 ; 19
(1
): 52
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Cilostazol-induced acute tubulointerstitial nephritis accompanied by IgA
nephropathy: a case report
#MMPMID29506491
Shima H
; Tashiro M
; Yamada S
; Matsuura M
; Okada K
; Doi T
; Minakuchi J
; Kawashima S
BMC Nephrol
2018[Mar]; 19
(1
): 52
PMID29506491
show ga
BACKGROUND: Cilostazol is an antiplatelet drug that is widely prescribed for the
prevention of secondary stroke. Adverse reactions to cilostazol include
headaches, palpitations, and diarrhea. Little is known about the nephrotoxicity
of cilostazol, such as acute kidney injury. We report a biopsy-proven case of
diffuse tubulointerstitial nephritis induced by cilostazol. CASE PRESENTATION: A
69-year-old woman prescribed cilostazol was hospitalized for acute kidney injury.
On admission, her renal function deteriorated, with an increased serum creatinine
level. Urinalysis showed hematuria, proteinuria, and
hyper-beta2-microglobulinuria. A renal biopsy revealed diffuse tubulointerstitial
nephritis associated with IgA nephropathy, and gallium-67 scintigraphy showed
uptake in the bilateral kidneys. A drug lymphocyte stimulation test for
cilostazol was positive, and the patient was diagnosed with cilostazol-induced
acute tubulointerstitial nephritis. Despite discontinuation of cilostazol, her
renal function rapidly worsened and steroid pulse therapy was initiated, followed
by oral high-dose glucocorticoid therapy. After steroid treatment, her serum
creatinine level normalized in parallel with urine beta2-microglobulin.
CONCLUSION: Cilostazol can induce acute tubulointerstitial nephritis.