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10.1186/s13046-018-0713-7 http://scihub22266oqcxt.onion/10.1186/s13046-018-0713-7 C5838931!5838931 !29506555     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29506555 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Exp+Clin+Cancer+Res 2018 ; 37 (1 ): 44 Nephropedia Template TP {{tp|p=29506555 |t=2018. Blockade of TIM3 relieves immunosuppression through reducing regulatory T cells in head and neck cancer |pdf=|usr=}}{{29506555 }} gab.com Text Blockade of TIM3 relieves immunosuppression through reducing regulatory T cells in head and neck cancer JO: J Exp Clin Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=29506555 #FOAvip BACKGROUND: T-cell immunoglobulin mucin 3 (TIM3) is a negative immune checkpoint and plays a crucial part in tumor-induced immune suppression. However, the mechanism of TIM3 in regulating immunosuppression in head and neck squamous cell carcinoma (HNSCC) was still not quite clear. METHODS: We carried out the immunohistochemistry staining of HNSCC tissue microarrays. Through quantification of the histoscore, we performed the correlation analysis among the TIM3, Galectin-9, Foxp3, CD68 and CD163. The effects of TIM3 on regulatory T cells (Tregs) and macrophages were detected by utilizing the Tgfbr1/Pten 2cKO HNSCC mouse model. Flow cytometry were used to analysis the percent of Tregs, macrophages and IFN-?. RESULTS: We demonstrated the close association among TIM3/Galectin-9 pathway, regulatory T cell marker (Foxp3) and macrophage marker (CD68, CD163) in human HNSCC. In the transgenic HNSCC mouse model, blockade of TIM3 by the anti-TIM3 monoclonal antibody induced a reduction of CD4(+)CD25(+)Foxp3(+) Tregs. Meanwhile, the population of TIM3(+) Tregs was also decreased. However, the population of CD206(+) macrophages was not significantly declined. The increased IFN-? production on CD8(+) T cells in anti-TIM3 treatment mice showed that the antitumor immune response was enhanced through suppression of these negative immune factors. CONCLUSIONS: The present study demonstrated that TIM3 was associated with the immunosuppression in HNSCC. And targeting TIM3 can enhance anti-tumor immune response by decreasing Tregs in HNSCC. Twit Text FOAVip Blockade of TIM3 relieves immunosuppression through reducing regulatory T cells in head and neck cancer ????J Exp Clin Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=29506555 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29506555 #FOAvip English Wikipedia <ref>{{Cite pmid|29506555 }}</ref> Blockade of TIM3 relieves immunosuppression through reducing regulatory T cells in head and neck cancer #MMPMID29506555 Liu JF ; Wu L ; Yang LL ; Deng WW ; Mao L ; Wu H ; Zhang WF ; Sun ZJ J Exp Clin Cancer Res 2018[Mar]; 37 (1 ): 44 PMID29506555 show ga BACKGROUND: T-cell immunoglobulin mucin 3 (TIM3) is a negative immune checkpoint and plays a crucial part in tumor-induced immune suppression. However, the mechanism of TIM3 in regulating immunosuppression in head and neck squamous cell carcinoma (HNSCC) was still not quite clear. METHODS: We carried out the immunohistochemistry staining of HNSCC tissue microarrays. Through quantification of the histoscore, we performed the correlation analysis among the TIM3, Galectin-9, Foxp3, CD68 and CD163. The effects of TIM3 on regulatory T cells (Tregs) and macrophages were detected by utilizing the Tgfbr1/Pten 2cKO HNSCC mouse model. Flow cytometry were used to analysis the percent of Tregs, macrophages and IFN-?. RESULTS: We demonstrated the close association among TIM3/Galectin-9 pathway, regulatory T cell marker (Foxp3) and macrophage marker (CD68, CD163) in human HNSCC. In the transgenic HNSCC mouse model, blockade of TIM3 by the anti-TIM3 monoclonal antibody induced a reduction of CD4(+)CD25(+)Foxp3(+) Tregs. Meanwhile, the population of TIM3(+) Tregs was also decreased. However, the population of CD206(+) macrophages was not significantly declined. The increased IFN-? production on CD8(+) T cells in anti-TIM3 treatment mice showed that the antitumor immune response was enhanced through suppression of these negative immune factors. CONCLUSIONS: The present study demonstrated that TIM3 was associated with the immunosuppression in HNSCC. And targeting TIM3 can enhance anti-tumor immune response by decreasing Tregs in HNSCC. |*Immune Tolerance [MESH] |Animals [MESH] |Biomarkers [MESH] |CD8-Positive T-Lymphocytes/immunology/metabolism [MESH] |Disease Models, Animal [MESH] |Gene Expression Profiling [MESH] |Head and Neck Neoplasms/*immunology/*metabolism [MESH] |Hepatitis A Virus Cellular Receptor 2/*antagonists & inhibitors [MESH] |Humans [MESH] |Immunohistochemistry [MESH] |Immunophenotyping [MESH] |Interferon-gamma [MESH] |Macrophages/immunology/metabolism [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Signal Transduction [MESH]Blockade of TIM3 relieves immunosuppression through reducing regulator(epmc).pdf DeepDyve Pubget Overpricing