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10.1093/ndt/gfw393 http://scihub22266oqcxt.onion/10.1093/ndt/gfw393 C5837383!5837383!28064162     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nephrol+Dial+Transplant 2017 ; 32 (7): 1137-45 Nephropedia Template TP {{tp|p=28064162|t=2017. Acute genetic ablation of pendrin lowers blood pressure in mice |pdf=|usr=}}{{28064162}} gab.com Text Acute genetic ablation of pendrin lowers blood pressure in mice JO: Nephrol Dial Transplant http://www.kidney.de/pget.php?&tw=1&pmid=28064162 #FOAvip Background. Pendrin, the chloride/bicarbonate exchanger of ?-intercalated cells of the renal connecting tubule and the collecting duct, plays a key role in NaCl reabsorption by the distal nephron. Therefore, pendrin may be important for the control of extracellular fluid volume and blood pressure.Methods. Here, we have used a genetic mouse model in which the expression of pendrin can be switched-on in vivo by the administration of doxycycline. Pendrin can also be rapidly removed when doxycycline administration is discontinued. Therefore, our genetic strategy allows us to test selectively the acute effects of loss of pendrin function.Results. We show that acute loss of pendrin leads to a significant decrease of blood pressure. In addition, acute ablation of pendrin did not alter significantly the acid-base status or blood K+?concentration.Conclusion. By using a transgenic mouse model, avoiding off-target effects related to pharmacological compounds, this study suggests that pendrin could be a novel target to treat hypertension. Twit Text FOAVip Acute genetic ablation of pendrin lowers blood pressure in mice ????Nephrol Dial Transplant http://www.kidney.de/pget.php?&tw=1&pmid=28064162 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28064162 #FOAvip English Wikipedia <ref>{{Cite pmid|28064162}}</ref> Acute genetic ablation of pendrin lowers blood pressure in mice #MMPMID28064162 Trepiccione F; Soukaseum C; Baudrie V; Kumai Y; Teulon J; Villoutreix B; Cornière N; Wangemann P; Griffith AJ; Byung Choi Y; Hadchouel J; Chambrey R; Eladari D Nephrol Dial Transplant 2017[Jul]; 32 (7): 1137-45 PMID28064162show ga Background. Pendrin, the chloride/bicarbonate exchanger of ?-intercalated cells of the renal connecting tubule and the collecting duct, plays a key role in NaCl reabsorption by the distal nephron. Therefore, pendrin may be important for the control of extracellular fluid volume and blood pressure.Methods. Here, we have used a genetic mouse model in which the expression of pendrin can be switched-on in vivo by the administration of doxycycline. Pendrin can also be rapidly removed when doxycycline administration is discontinued. Therefore, our genetic strategy allows us to test selectively the acute effects of loss of pendrin function.Results. We show that acute loss of pendrin leads to a significant decrease of blood pressure. In addition, acute ablation of pendrin did not alter significantly the acid-base status or blood K+?concentration.Conclusion. By using a transgenic mouse model, avoiding off-target effects related to pharmacological compounds, this study suggests that pendrin could be a novel target to treat hypertension. äAcute genetic ablation of pendrin lowers blood pressure in mice (epmc).pdf DeepDyve Pubget Overpricing