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10.1002/uog.17373 http://scihub22266oqcxt.onion/10.1002/uog.17373 C5836987!5836987!27883242     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Ultrasound+Obstet+Gynecol 2017 ; 50 (3): 373-82 Nephropedia Template TP {{tp|p=27883242|t=2017. sFlt?1/PlGF for prediction of early?onset pre?eclampsia: STEPS (Study of Early Pre?eclampsia in Spain) |pdf=|usr=}}{{27883242}} gab.com Text sFlt 1/PlGF for prediction of early onset pre eclampsia: STEPS (Study of Early Pre eclampsia in Spain) JO: Ultrasound Obstet Gynecol http://www.kidney.de/pget.php?&tw=1&pmid=27883242 #FOAvip Objective: A high ratio of soluble fms?like tyrosine kinase?1 (sFlt?1) to placental growth factor (PlGF) has been linked to pre?eclampsia (PE). We evaluated the sFlt?1/PlGF ratio as a predictive marker for early?onset PE in women at risk of PE. Methods: This prospective, Spanish, multicenter study included pregnant women with a risk factor for PE, including intrauterine growth restriction, PE, eclampsia or hemolysis, elevated liver enzymes and low platelet count syndrome in previous pregnancy, pregestational diabetes or abnormal uterine artery Doppler. The primary objective was to show that the sFlt?1/PlGF ratio at 20, 24 and 28 weeks' gestation was predictive of early?onset PE (< 34 + 0 weeks). Serum sFlt?1 and PlGF were measured at 20, 24 and 28 weeks. Multivariate logistic regression was used to develop a predictive model. Results: A total of 819 women were enrolled, of which 729 were suitable for analysis. Of these, 78 (10.7%) women developed PE (24 early onset and 54 late onset). Median sFlt?1/PlGF ratio at 20, 24 and 28 weeks was 6.3 (interquartile range (IQR), 4.1?9.3), 4.0 (IQR, 2.6?6.3) and 3.3 (IQR, 2.0?5.9), respectively, for women who did not develop PE (controls); 14.5 (IQR, 5.5?43.7), 18.4 (IQR, 8.2?57.9) and 51.9 (IQR, 11.5?145.6) for women with early?onset PE; and 6.7 (IQR, 4.6?9.9), 4.7 (IQR, 2.8?7.2) and 6.0 (IQR, 3.8?10.5) for women with late?onset PE. Compared with early?onset PE, the sFlt?1/PlGF ratio was significantly lower in controls (P < 0.001 at each timepoint) and in women with chronic hypertension (P < 0.001 at each timepoint), gestational hypertension (P < 0.001 at each timepoint) and late?onset PE (P < 0.001 at each timepoint). A prediction model for early?onset PE was developed, which included the sFlt?1/PlGF ratio plus mean arterial pressure, being parous and previous PE, with areas under the receiver?operating characteristics curves of 0.86 (95% CI, 0.77?0.95), 0.91 (95% CI, 0.85?0.97) and 0.93 (95% CI, 0.86?0.99) at 20, 24 and 28 weeks, respectively, and was superior to models using the sFlt?1/PlGF ratio alone or uterine artery mean pulsatility index. Conclusions: The sFlt?1/PlGF ratio can improve prediction of early?onset PE for women at risk of this condition. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd. Twit Text FOAVip sFlt 1/PlGF for prediction of early onset pre eclampsia: STEPS (Study of Early Pre eclampsia in Spain) ????Ultrasound Obstet Gynecol http://www.kidney.de/pget.php?&tw=1&pmid=27883242 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27883242 #FOAvip English Wikipedia <ref>{{Cite pmid|27883242}}</ref> sFlt?1/PlGF for prediction of early?onset pre?eclampsia: STEPS (Study of Early Pre?eclampsia in Spain) #MMPMID27883242 Perales A; Delgado JL; de la Calle M; García?Hernández JA; Escudero AI; Campillos JM; Sarabia MD; Laíz B; Duque M; Navarro M; Calmarza P; Hund M; Álvarez FV Ultrasound Obstet Gynecol 2017[Sep]; 50 (3): 373-82 PMID27883242show ga Objective: A high ratio of soluble fms?like tyrosine kinase?1 (sFlt?1) to placental growth factor (PlGF) has been linked to pre?eclampsia (PE). We evaluated the sFlt?1/PlGF ratio as a predictive marker for early?onset PE in women at risk of PE. Methods: This prospective, Spanish, multicenter study included pregnant women with a risk factor for PE, including intrauterine growth restriction, PE, eclampsia or hemolysis, elevated liver enzymes and low platelet count syndrome in previous pregnancy, pregestational diabetes or abnormal uterine artery Doppler. The primary objective was to show that the sFlt?1/PlGF ratio at 20, 24 and 28 weeks' gestation was predictive of early?onset PE (< 34 + 0 weeks). Serum sFlt?1 and PlGF were measured at 20, 24 and 28 weeks. Multivariate logistic regression was used to develop a predictive model. Results: A total of 819 women were enrolled, of which 729 were suitable for analysis. Of these, 78 (10.7%) women developed PE (24 early onset and 54 late onset). Median sFlt?1/PlGF ratio at 20, 24 and 28 weeks was 6.3 (interquartile range (IQR), 4.1?9.3), 4.0 (IQR, 2.6?6.3) and 3.3 (IQR, 2.0?5.9), respectively, for women who did not develop PE (controls); 14.5 (IQR, 5.5?43.7), 18.4 (IQR, 8.2?57.9) and 51.9 (IQR, 11.5?145.6) for women with early?onset PE; and 6.7 (IQR, 4.6?9.9), 4.7 (IQR, 2.8?7.2) and 6.0 (IQR, 3.8?10.5) for women with late?onset PE. Compared with early?onset PE, the sFlt?1/PlGF ratio was significantly lower in controls (P < 0.001 at each timepoint) and in women with chronic hypertension (P < 0.001 at each timepoint), gestational hypertension (P < 0.001 at each timepoint) and late?onset PE (P < 0.001 at each timepoint). A prediction model for early?onset PE was developed, which included the sFlt?1/PlGF ratio plus mean arterial pressure, being parous and previous PE, with areas under the receiver?operating characteristics curves of 0.86 (95% CI, 0.77?0.95), 0.91 (95% CI, 0.85?0.97) and 0.93 (95% CI, 0.86?0.99) at 20, 24 and 28 weeks, respectively, and was superior to models using the sFlt?1/PlGF ratio alone or uterine artery mean pulsatility index. Conclusions: The sFlt?1/PlGF ratio can improve prediction of early?onset PE for women at risk of this condition. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd. äsFlt?1/PlGF for prediction of early?onset pre?eclampsia: STEPS (Study (epmc).pdf DeepDyve Pubget Overpricing