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10.1186/s12864-018-4477-4 http://scihub22266oqcxt.onion/10.1186/s12864-018-4477-4 C5836836!5836836!29504907     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       BMC+Genomics 2018 ; 19 (Suppl 3): ä Nephropedia Template TP {{tp|p=29504907|t=2018. HK3 overexpression associated with epithelial-mesenchymal transition in colorectal cancer |pdf=|usr=}}{{29504907}} gab.com Text HK3 overexpression associated with epithelial-mesenchymal transition in colorectal cancer JO: BMC Genomics http://www.kidney.de/pget.php?&tw=1&pmid=29504907 #FOAvip Background: Colorectal cancer (CRC) is a common cancer worldwide. The main cause of death in CRC includes tumor progression and metastasis. At molecular level, these processes may be triggered by epithelial-mesenchymal transition (EMT) and necessitates specific alterations in cell metabolism. Although several EMT-related metabolic changes have been described in CRC, the mechanism is still poorly understood. Results: Using CrossHub software, we analyzed RNA-Seq expression profile data of CRC derived from The Cancer Genome Atlas (TCGA) project. Correlation analysis between the change in the expression of genes involved in glycolysis and EMT was performed. We obtained the set of genes with significant correlation coefficients, which included 21 EMT-related genes and a single glycolytic gene, HK3. The mRNA level of these genes was measured in 78 paired colorectal cancer samples by quantitative polymerase chain reaction (qPCR). Upregulation of HK3 and deregulation of 11 genes (COL1A1, TWIST1, NFATC1, GLIPR2, SFPR1, FLNA, GREM1, SFRP2, ZEB2, SPP1, and RARRES1) involved in EMT were found. The results of correlation study showed that the expression of HK3 demonstrated a strong correlation with 7 of the 21 examined genes (ZEB2, GREM1, TGFB3, TGFB1, SNAI2, TWIST1, and COL1A1) in CRC. Conclusions: Upregulation of HK3 is associated with EMT in CRC and may be a crucial metabolic adaptation for rapid proliferation, survival, and metastases of CRC cells. Electronic supplementary material: The online version of this article (10.1186/s12864-018-4477-4) contains supplementary material, which is available to authorized users. Twit Text FOAVip HK3 overexpression associated with epithelial-mesenchymal transition in colorectal cancer ????BMC Genomics http://www.kidney.de/pget.php?&tw=1&pmid=29504907 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29504907 #FOAvip English Wikipedia <ref>{{Cite pmid|29504907}}</ref> HK3 overexpression associated with epithelial-mesenchymal transition in colorectal cancer #MMPMID29504907 Pudova EA; Kudryavtseva AV; Fedorova MS; Zaretsky AR; Shcherbo DS; Lukyanova EN; Popov AY; Sadritdinova AF; Abramov IS; Kharitonov SL; Krasnov GS; Klimina KM; Koroban NV; Volchenko NN; Nyushko KM; Melnikova NV; Chernichenko MA; Sidorov DV; Alekseev BY; Kiseleva MV; Kaprin AD; Dmitriev AA; Snezhkina AV BMC Genomics 2018[]; 19 (Suppl 3): ä PMID29504907show ga Background: Colorectal cancer (CRC) is a common cancer worldwide. The main cause of death in CRC includes tumor progression and metastasis. At molecular level, these processes may be triggered by epithelial-mesenchymal transition (EMT) and necessitates specific alterations in cell metabolism. Although several EMT-related metabolic changes have been described in CRC, the mechanism is still poorly understood. Results: Using CrossHub software, we analyzed RNA-Seq expression profile data of CRC derived from The Cancer Genome Atlas (TCGA) project. Correlation analysis between the change in the expression of genes involved in glycolysis and EMT was performed. We obtained the set of genes with significant correlation coefficients, which included 21 EMT-related genes and a single glycolytic gene, HK3. The mRNA level of these genes was measured in 78 paired colorectal cancer samples by quantitative polymerase chain reaction (qPCR). Upregulation of HK3 and deregulation of 11 genes (COL1A1, TWIST1, NFATC1, GLIPR2, SFPR1, FLNA, GREM1, SFRP2, ZEB2, SPP1, and RARRES1) involved in EMT were found. The results of correlation study showed that the expression of HK3 demonstrated a strong correlation with 7 of the 21 examined genes (ZEB2, GREM1, TGFB3, TGFB1, SNAI2, TWIST1, and COL1A1) in CRC. Conclusions: Upregulation of HK3 is associated with EMT in CRC and may be a crucial metabolic adaptation for rapid proliferation, survival, and metastases of CRC cells. Electronic supplementary material: The online version of this article (10.1186/s12864-018-4477-4) contains supplementary material, which is available to authorized users. äHK3 overexpression associated with epithelial-mesenchymal transition i(epmc).pdf DeepDyve Pubget Overpricing