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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Biol+Chem 2018 ; 293 (9): 3252-3 Nephropedia Template TP
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How MHC molecules grab citrullinated peptides to foster rheumatoid arthritis #MMPMID29500270
Margulies DH
J Biol Chem 2018[Mar]; 293 (9): 3252-3 PMID29500270show ga
The molecular immunologist's dream is to elucidate a fundamental biochemical process that explains the basis of an affliction that affects millions of people, and that, precisely understood, might yield a rational approach to diagnosis, prevention, or therapy. In this issue of JBC, Ting et al. report proteomic, biochemical, and structural analyses that better explain how the antigen-presenting HLA-DR4 molecules bind citrullinated peptides to provoke rheumatoid arthritis (RA), a chronic autoimmune disease that affects 0.5?1% of the population.