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10.1074/jbc.H118.001829

http://scihub22266oqcxt.onion/10.1074/jbc.H118.001829
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C5836129!5836129!29500270
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suck abstract from ncbi


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pmid29500270      J+Biol+Chem 2018 ; 293 (9): 3252-3
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  • How MHC molecules grab citrullinated peptides to foster rheumatoid arthritis #MMPMID29500270
  • Margulies DH
  • J Biol Chem 2018[Mar]; 293 (9): 3252-3 PMID29500270show ga
  • The molecular immunologist's dream is to elucidate a fundamental biochemical process that explains the basis of an affliction that affects millions of people, and that, precisely understood, might yield a rational approach to diagnosis, prevention, or therapy. In this issue of JBC, Ting et al. report proteomic, biochemical, and structural analyses that better explain how the antigen-presenting HLA-DR4 molecules bind citrullinated peptides to provoke rheumatoid arthritis (RA), a chronic autoimmune disease that affects 0.5?1% of the population.
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